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Mechanisms of antimicrobial resistance in Gram-negative bacilli

Overview of attention for article published in Annals of Intensive Care, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
1 blog
twitter
13 X users
facebook
1 Facebook page
googleplus
1 Google+ user
reddit
1 Redditor

Citations

dimensions_citation
321 Dimensions

Readers on

mendeley
1009 Mendeley
Title
Mechanisms of antimicrobial resistance in Gram-negative bacilli
Published in
Annals of Intensive Care, August 2015
DOI 10.1186/s13613-015-0061-0
Pubmed ID
Authors

Étienne Ruppé, Paul-Louis Woerther, François Barbier

Abstract

The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In Enterobacteriaceae, the dramatic increase in the rates of resistance to third-generation cephalosporins mainly results from the spread of plasmid-borne extended-spectrum beta-lactamase (ESBL), especially those belonging to the CTX-M family. The efficacy of beta-lactam/beta-lactamase inhibitor associations for severe infections due to ESBL-producing Enterobacteriaceae has not been adequately evaluated in critically ill patients, and carbapenems still stands as the first-line choice in this situation. However, carbapenemase-producing strains have emerged worldwide over the past decade. VIM- and NDM-type metallo-beta-lactamases, OXA-48 and KPC appear as the most successful enzymes and may threaten the efficacy of carbapenems in the near future. ESBL- and carbapenemase-encoding plasmids frequently bear resistance determinants for other antimicrobial classes, including aminoglycosides (aminoglycoside-modifying enzymes or 16S rRNA methylases) and fluoroquinolones (Qnr, AAC(6')-Ib-cr or efflux pumps), a key feature that fosters the spread of multidrug resistance in Enterobacteriaceae. In non-fermenting GNB such as Pseudomonas aeruginosa, Acinetobacter baumannii and Stenotrophomonas maltophilia, multidrug resistance may emerge following the sole occurrence of sequential chromosomal mutations, which may lead to the overproduction of intrinsic beta-lactamases, hyper-expression of efflux pumps, target modifications and permeability alterations. P. aeruginosa and A. baumannii also have the ability to acquire mobile genetic elements encoding resistance determinants, including carbapenemases. Available options for the treatment of ICU-acquired infections due to carbapenem-resistant GNB are currently scarce, and recent reports emphasizing the spread of colistin resistance in environments with high volume of polymyxins use elicit major concern.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,009 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 1008 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 133 13%
Student > Bachelor 132 13%
Student > Ph. D. Student 99 10%
Researcher 88 9%
Student > Postgraduate 81 8%
Other 172 17%
Unknown 304 30%
Readers by discipline Count As %
Medicine and Dentistry 189 19%
Immunology and Microbiology 150 15%
Biochemistry, Genetics and Molecular Biology 109 11%
Agricultural and Biological Sciences 93 9%
Pharmacology, Toxicology and Pharmaceutical Science 31 3%
Other 104 10%
Unknown 333 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2021.
All research outputs
#1,963,080
of 22,821,814 outputs
Outputs from Annals of Intensive Care
#239
of 1,043 outputs
Outputs of similar age
#27,316
of 264,494 outputs
Outputs of similar age from Annals of Intensive Care
#2
of 10 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,043 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,494 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.