Title |
Simultaneous dual-contrast multi-phase liver imaging using spectral photon-counting computed tomography: a proof-of-concept study
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Published in |
European Radiology Experimental, December 2017
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DOI | 10.1186/s41747-017-0030-5 |
Pubmed ID | |
Authors |
Daniela Muenzel, Heiner Daerr, Roland Proksa, Alexander A. Fingerle, Felix K. Kopp, Philippe Douek, Julia Herzen, Franz Pfeiffer, Ernst J. Rummeny, Peter B. Noël |
Abstract |
To assess the feasibility of dual-contrast spectral photon-counting computed tomography (SPCCT) for liver imaging. We present an SPCCT in-silico study for simultaneous mapping of the complementary distribution in the liver of two contrast agents (CAs) subsequently intravenously injected: a gadolinium-based contrast agent and an iodine-based contrast agent. Four types of simulated liver lesions with a characteristic arterial and portal venous pattern (haemangioma, hepatocellular carcinoma, cyst, and metastasis) are presented. A material decomposition was performed to reconstruct quantitative iodine and gadolinium maps. Finally, a multi-dimensional classification algorithm for automatic lesion detection is presented. Our simulations showed that with a single-scan SPCCT and an adapted contrast injection protocol, it was possible to reconstruct contrast-enhanced images of the liver with arterial distribution of the iodine-based CA and portal venous phase of the gadolinium-based CA. The characteristic patterns of contrast enhancement were visible in all liver lesions. The approach allowed for an automatic detection and classification of liver lesions using a multi-dimensional analysis. Dual-contrast SPCCT should be able to visualise the characteristic arterial and portal venous enhancement with a single scan, allowing for an automatic lesion detection and characterisation, with a reduced radiation exposure. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 50% |
Austria | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 13% |
Student > Bachelor | 4 | 9% |
Other | 4 | 9% |
Researcher | 4 | 9% |
Student > Master | 4 | 9% |
Other | 9 | 19% |
Unknown | 16 | 34% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 23% |
Engineering | 5 | 11% |
Physics and Astronomy | 3 | 6% |
Nursing and Health Professions | 2 | 4% |
Psychology | 2 | 4% |
Other | 5 | 11% |
Unknown | 19 | 40% |