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Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics

Overview of attention for article published in Breast Cancer Research and Treatment, March 2018
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14 Mendeley
Title
Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics
Published in
Breast Cancer Research and Treatment, March 2018
DOI 10.1007/s10549-018-4735-9
Pubmed ID
Authors

Megan S. Rice, Rulla M. Tamimi, Kimberly A. Bertrand, Christopher G. Scott, Matthew R. Jensen, Aaron D. Norman, Daniel W. Visscher, Yunn-Yi Chen, Kathleen R. Brandt, Fergus J. Couch, John A. Shepherd, Bo Fan, Fang-Fang Wu, Lin Ma, Laura C. Collins, Steven R. Cummings, Karla Kerlikowske, Celine M. Vachon

Abstract

Though mammographic density (MD) has been proposed as an intermediate marker of breast cancer risk, few studies have examined whether the associations between breast cancer risk factors and risk are mediated by MD, particularly by tumor characteristics. Our study population included 3392 cases (1105 premenopausal) and 8882 (3192 premenopausal) controls from four case-control studies. For established risk factors, we estimated the percent of the total risk factor association with breast cancer that was mediated by percent MD (secondarily, by dense area and non-dense area) for invasive breast cancer as well as for subtypes defined by the estrogen receptor (ER+/ER-), progesterone receptor (PR+/PR-), and HER2 (HER2+/HER2-). Analyses were conducted separately in pre- and postmenopausal women. Positive associations between prior breast biopsy and risk of invasive breast cancer as well as all subtypes were partially mediated by percent MD in pre- and postmenopausal women (percent mediated = 11-27%, p ≤ 0.02). In postmenopausal women, nulliparity and hormone therapy use were positively associated with invasive, ER+ , PR+ , and HER2- breast cancer; percent MD partially mediated these associations (percent mediated ≥ 31%, p ≤ 0.02). Further, among postmenopausal women, percent MD partially mediated the positive association between later age at first birth and invasive as well as ER+ breast cancer (percent mediated = 16%, p ≤ 0.05). Percent MD partially mediated the associations between breast biopsy, nulliparity, age at first birth, and hormone therapy with risk of breast cancer, particularly among postmenopausal women, suggesting that these risk factors at least partially influence breast cancer risk through changes in breast tissue composition.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 3 21%
Researcher 2 14%
Other 2 14%
Student > Master 2 14%
Student > Postgraduate 1 7%
Other 4 29%
Readers by discipline Count As %
Medicine and Dentistry 6 43%
Unspecified 5 36%
Nursing and Health Professions 2 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2018.
All research outputs
#8,202,005
of 13,079,903 outputs
Outputs from Breast Cancer Research and Treatment
#2,233
of 3,223 outputs
Outputs of similar age
#162,389
of 270,352 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#36
of 61 outputs
Altmetric has tracked 13,079,903 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,223 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,352 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.