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From underlying chemistry to therapeutic potential: open questions in the new field of lysine polyphosphorylation

Overview of attention for article published in Current Genetics, June 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

twitter
13 tweeters

Citations

dimensions_citation
5 Dimensions

Readers on

mendeley
9 Mendeley
Title
From underlying chemistry to therapeutic potential: open questions in the new field of lysine polyphosphorylation
Published in
Current Genetics, June 2018
DOI 10.1007/s00294-018-0854-4
Pubmed ID
Authors

Amanda Bentley-DeSousa, Michael Downey

Abstract

Polyphosphorylation is a newly described non-enzymatic post-translational modification wherein long chains of inorganic phosphates are attached to lysine residues. The first targets of polyphosphorylation identified were S. cerevisiae proteins Nsr1 and Top1. Building on this theme, we recently exploited functional genomics tools in yeast to identify 15 new targets, including a conserved network of nucleolar proteins implicated in ribosome biogenesis. We also described the polyphosphorylation of six human proteins, suggesting that this unique post-translational modification could be conserved throughout eukaryotes. The study of polyphosphorylation seems poised to uncover novel modes of protein regulation in pathways spanning diverse biological processes. In this review, we establish a framework for future work by outlining critical questions related to the biochemistry of polyphosphorylation, its therapeutic potential, and everything in between.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 33%
Student > Bachelor 3 33%
Student > Master 2 22%
Unknown 1 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 78%
Medicine and Dentistry 1 11%
Unknown 1 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2018.
All research outputs
#2,438,869
of 13,796,475 outputs
Outputs from Current Genetics
#84
of 981 outputs
Outputs of similar age
#71,330
of 273,620 outputs
Outputs of similar age from Current Genetics
#1
of 14 outputs
Altmetric has tracked 13,796,475 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 981 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,620 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.