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The in vitro protective effect of salicylic acid against paclitaxel and cisplatin-induced neurotoxicity

Overview of attention for article published in Cytotechnology, July 2015
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About this Attention Score

  • Among the highest-scoring outputs from this source (#43 of 164)
  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

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1 tweeter
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2 Facebook pages

Citations

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8 Dimensions

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8 Mendeley
Title
The in vitro protective effect of salicylic acid against paclitaxel and cisplatin-induced neurotoxicity
Published in
Cytotechnology, July 2015
DOI 10.1007/s10616-015-9896-3
Pubmed ID
Authors

Damla Cetin, Ahmet Hacımuftuoglu, Abdulgani Tatar, Hasan Turkez, Basak Togar

Abstract

Paclitaxel (PAC) and cisplatin (CIS) are two established chemotherapeutic drugs used in combination for the treatment of various solid tumors. However, the usage of PAC and CIS are limited because of the incidence of their moderate or severe neurotoxic side effects. In this study, we aimed to assess the protective role of salicylic acid (SA) against neurotoxicity caused by PAC and CIS. For this purpose, newborn Sprague Dawley rats were decapitated in sterile atmosphere and primary cortex neuron cultures were established. On the 10th day SA was added into culture plates. PAC and CIS were added on the 12th day. The cytotoxicity was determined by using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. Oxidative alterations were assessed using total antioxidant capacity and total oxidative stress assays in rat primary neuron cell cultures. It was shown that both concentrations of PAC and CIS treatments caused neurotoxicity. Although SA decreased the neurotoxicity by CIS and PAC, it was more effective against the toxicity caused by CIS rather than the toxicity caused by PAC. In conclusion it was clearly revealed that SA decreased the neurotoxic effect of CIS and PAC in vitro.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 25%
Student > Master 2 25%
Unspecified 2 25%
Student > Doctoral Student 1 13%
Student > Ph. D. Student 1 13%
Other 0 0%
Readers by discipline Count As %
Unspecified 3 38%
Agricultural and Biological Sciences 2 25%
Nursing and Health Professions 1 13%
Biochemistry, Genetics and Molecular Biology 1 13%
Medicine and Dentistry 1 13%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2015.
All research outputs
#2,502,489
of 5,422,157 outputs
Outputs from Cytotechnology
#43
of 164 outputs
Outputs of similar age
#85,715
of 189,470 outputs
Outputs of similar age from Cytotechnology
#1
of 8 outputs
Altmetric has tracked 5,422,157 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 164 research outputs from this source. They receive a mean Attention Score of 1.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,470 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them