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Magnetisation transfer as a biomarker for chronic airway fibrosis in a mouse lung transplantation model

Overview of attention for article published in European Radiology Experimental, February 2018
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Title
Magnetisation transfer as a biomarker for chronic airway fibrosis in a mouse lung transplantation model
Published in
European Radiology Experimental, February 2018
DOI 10.1186/s41747-017-0032-3
Pubmed ID
Authors

David Kenkel, Yoshito Yamada, Markus Weiger, Moritz C. Wurnig, Wolfgang Jungraithmayr, Andreas Boss

Abstract

Chronic airway fibrosis (CAF) is the most prevalent complication in human lung transplant recipients. The aim of the study is to evaluate magnetisation transfer (MT) as a biomarker of developing CAF of lung transplants in a mouse model. Lung transplantation was performed in 48 mice, applying major or minor histocompatibility mismatches between strains for the induction of CAF. MT measurements were performed in vivo with systematic variation of off-resonance frequencies and flip angle of the MT prepulse. MT ratios (MTRs) were compared for lungs showing CAF and without CAF. Seven out of 24 animals (29%) showed a pattern of CAF at histology. All mice developing CAF also showed signs of acute rejection, whereas none of the lungs showed signs of other post-transplant complications. After lung transplantation, pulmonary infiltration was a frequent finding (14 out of 24) exhibiting a higher MTR (24.8% ± 4.5%) compared to well-ventilated lungs (12.3% ± 6.9%, p = 0.001) at 8000 Hz off-resonance frequency, 3000° flip angle. In infiltrated lung tissue exhibiting CAF, lower MTR values (21.8% ± 5.7%) were found compared to infiltrated lungs showing signs of acute rejection alone (26.5% ± 2.9%, p = 0.028), at 8000 Hz, 3000° flip angle. The highest MTR values were observed at 3000° flip angle, using a 1000 Hz off-resonance frequency. MTR might serve as a tool for the detection of CAF in infiltrated lung tissue.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 18%
Researcher 2 18%
Student > Doctoral Student 1 9%
Student > Master 1 9%
Professor 1 9%
Other 1 9%
Unknown 3 27%
Readers by discipline Count As %
Immunology and Microbiology 2 18%
Medicine and Dentistry 2 18%
Biochemistry, Genetics and Molecular Biology 1 9%
Physics and Astronomy 1 9%
Nursing and Health Professions 1 9%
Other 1 9%
Unknown 3 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2018.
All research outputs
#7,834,966
of 13,589,098 outputs
Outputs from European Radiology Experimental
#46
of 69 outputs
Outputs of similar age
#140,195
of 270,453 outputs
Outputs of similar age from European Radiology Experimental
#1
of 1 outputs
Altmetric has tracked 13,589,098 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 69 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them