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Influence of 4-week multi-strain probiotic administration on resting-state functional connectivity in healthy volunteers

Overview of attention for article published in European Journal of Nutrition, May 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
4 tweeters

Citations

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13 Dimensions

Readers on

mendeley
45 Mendeley
Title
Influence of 4-week multi-strain probiotic administration on resting-state functional connectivity in healthy volunteers
Published in
European Journal of Nutrition, May 2018
DOI 10.1007/s00394-018-1732-z
Pubmed ID
Authors

Deepika Bagga, Christoph Stefan Aigner, Johanna Louise Reichert, Cinzia Cecchetto, Florian Ph. S. Fischmeister, Peter Holzer, Christine Moissl-Eichinger, Veronika Schöpf

Abstract

Experimental investigations in rodents have contributed significantly to our current understanding of the potential importance of the gut microbiome and brain interactions for neurotransmitter expression, neurodevelopment, and behaviour. However, clinical evidence to support such interactions is still scarce. The present study used a double-blind, randomized, pre- and post-intervention assessment design to investigate the effects of a 4-week multi-strain probiotic administration on whole-brain functional and structural connectivity in healthy volunteers. Forty-five healthy volunteers were recruited for this study and were divided equally into three groups (PRP: probiotic, PLP: placebo, and CON: control). All the participants underwent resting-state functional MRI and diffusion MRI brain scans twice during the course of study, at the beginning (time point 1) and after 4 weeks (time point 2). MRI data were acquired using a 3T whole-body MR system (Magnetom Skyra, Siemens, Germany). Functional connectivity (FC) changes were observed in the default mode network (DMN), salience network (SN), and middle and superior frontal gyrus network (MFGN) in the PRP group as compared to the PLP and CON groups. PRP group showed a significant decrease in FC in MFGN (in frontal pole and frontal medial cortex) and in DMN (in frontal lobe) as compared to CON and PLP groups, respectively. Further, significant increase in FC in SN (in cingulate gyrus and precuneus cortex) was also observed in PRP group as compared to CON group. The significance threshold was set to p < 0.05 FWE corrected. No significant structural differences were observed between the three groups. This work provides new insights into the role of a multi-strain probiotic administration in modulating the behaviour, which is reflected as changes in the FC in healthy volunteers. This study motivates future investigations into the role of probiotics in context of major depression and stress disorders.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 18%
Student > Master 8 18%
Student > Bachelor 7 16%
Researcher 7 16%
Student > Doctoral Student 5 11%
Other 10 22%
Readers by discipline Count As %
Neuroscience 9 20%
Psychology 7 16%
Unspecified 6 13%
Biochemistry, Genetics and Molecular Biology 6 13%
Nursing and Health Professions 5 11%
Other 12 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2019.
All research outputs
#680,150
of 13,511,623 outputs
Outputs from European Journal of Nutrition
#172
of 1,482 outputs
Outputs of similar age
#25,853
of 271,396 outputs
Outputs of similar age from European Journal of Nutrition
#6
of 33 outputs
Altmetric has tracked 13,511,623 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,482 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,396 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.