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Ghrelin knockout mice display defective skeletal muscle regeneration and impaired satellite cell self-renewal

Overview of attention for article published in Endocrine, May 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

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7 tweeters

Citations

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2 Dimensions

Readers on

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12 Mendeley
Title
Ghrelin knockout mice display defective skeletal muscle regeneration and impaired satellite cell self-renewal
Published in
Endocrine, May 2018
DOI 10.1007/s12020-018-1606-4
Pubmed ID
Authors

Elia Angelino, Simone Reano, Alessandro Bollo, Michele Ferrara, Marilisa De Feudis, Hana Sustova, Emanuela Agosti, Sara Clerici, Flavia Prodam, Catherine-Laure Tomasetto, Andrea Graziani, Nicoletta Filigheddu

Abstract

Muscle regeneration depends on satellite cells (SCs), quiescent precursors that, in consequence of injury or pathological states such as muscular dystrophies, activate, proliferate, and differentiate to repair the damaged tissue. A subset of SCs undergoes self-renewal, thus preserving the SC pool and its regenerative potential. The peptides produced by the ghrelin gene, i.e., acylated ghrelin (AG), unacylated ghrelin (UnAG), and obestatin (Ob), affect skeletal muscle biology in several ways, not always with overlapping effects. In particular, UnAG and Ob promote SC self-renewal and myoblast differentiation, thus fostering muscle regeneration. To delineate the endogenous contribution of preproghrelin in muscle regeneration, we evaluated the repair process in Ghrl -/- mice upon CTX-induced injury. Although muscles from Ghrl -/- mice do not visibly differ from WT muscles in term of weight, structure, and SCs content, muscle regeneration after CTX-induced injury is impaired in Ghrl -/- mice, indicating that ghrelin-derived peptides actively participate in muscle repair. Remarkably, the lack of ghrelin gene impacts SC self-renewal during regeneration. Although we cannot discern the specific Ghrl-derived peptide responsible for such activities, these data indicate that Ghrl contributes to a proper muscle regeneration.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 33%
Student > Master 1 8%
Student > Bachelor 1 8%
Student > Postgraduate 1 8%
Professor 1 8%
Other 4 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 50%
Agricultural and Biological Sciences 3 25%
Unspecified 1 8%
Immunology and Microbiology 1 8%
Medicine and Dentistry 1 8%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2018.
All research outputs
#3,539,892
of 13,043,953 outputs
Outputs from Endocrine
#149
of 917 outputs
Outputs of similar age
#94,105
of 271,531 outputs
Outputs of similar age from Endocrine
#4
of 22 outputs
Altmetric has tracked 13,043,953 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 917 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,531 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.