Title |
Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients
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Published in |
The Journal of Headache and Pain, February 2011
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DOI | 10.1007/s10194-011-0299-3 |
Pubmed ID | |
Authors |
Anita Trauninger, Eszter Leél-Őssy, David Olayinka Kamson, László Pótó, Mihály Aradi, Ferenc Kövér, Marianna Imre, Hedvig Komáromy, Szilvia Erdélyi-Botor, Ágnes Patzkó, Zoltán Pfund |
Abstract |
Brain white matter hyperintensities are more prevalent in migraine patients than in the general population, but the pathogenesis and the risk factors of these hyperintensities are not fully elucidated. The authors analyzed the routine clinical data of 186 migraine patients who were referred to the Outpatient Headache Department of the Department of Neurology, Medical School, University of Pécs, Hungary between 2007 and 2009: 58 patients with white matter hyperintensities and 128 patients without white matter hyperintensities on 3 T MRI. Significant associations between the presence of white matter hyperintensities and longer disease duration (14.4 vs. 19.9 years, p = 0.004), higher headache frequency (4.1 vs. 5.5 attacks/month, p = 0.017), hyperhomocysteinemia (incidence of hyperintensity is 9/9 = 100%, p = 0.009) and thyroid gland dysfunction (incidence of hyperintensity is 8/14 = 57.1%, p = 0.038) were found. These data support the theory that both the disease duration and the attack frequency have a key role in the formation of migraine-related brain white matter hyperintensities, but the effects of comorbid diseases may also contribute to the development of the hyperintensities. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Poland | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Scientists | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 2 | 4% |
Japan | 1 | 2% |
Australia | 1 | 2% |
Unknown | 48 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 21% |
Student > Ph. D. Student | 8 | 15% |
Student > Master | 6 | 12% |
Student > Bachelor | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Other | 7 | 13% |
Unknown | 13 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 22 | 42% |
Neuroscience | 5 | 10% |
Psychology | 2 | 4% |
Mathematics | 1 | 2% |
Business, Management and Accounting | 1 | 2% |
Other | 7 | 13% |
Unknown | 14 | 27% |