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Intestinal histopathological changes in a porcine model of pneumoperitoneum-induced intra-abdominal hypertension

Overview of attention for article published in Surgical Endoscopy, May 2018
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5 Mendeley
Title
Intestinal histopathological changes in a porcine model of pneumoperitoneum-induced intra-abdominal hypertension
Published in
Surgical Endoscopy, May 2018
DOI 10.1007/s00464-018-6142-z
Pubmed ID
Authors

Ester Párraga Ros, Laura Correa-Martín, Francisco M. Sánchez-Margallo, Irma Eugenia Candanosa-Aranda, Manu L. N. G. Malbrain, Robert Wise, Rafael Latorre, Octavio López Albors, Gregorio Castellanos

Abstract

Low splanchnic perfusion is an immediate effect of pneumoperitoneum-induced intra-abdominal hypertension (IAH). Anatomical structure results in the intestinal mucosa being the area most sensitive to hypoperfusion. The relationship between intestinal injury and clinical parameters of tissue perfusion [abdominal perfusion pressure (APP), gastric intramucosal pH (pHi) and lactic acid (Lc)] has not been previously studied. This study aimed to monitorize intestinal pathogenesis through sequential ileal biopsies and to measure APP, pHi, and Lc levels at different pneumoperitoneum-induced intra-abdominal pressures (20, 30, and 40 mmHg) to evaluate the potential relationships between them. Fifty pigs were divided into four groups; a control group (C) and three experimental groups with different pneumoperitoneum-induced levels [20 mmHg (G20), 30 mmHg (G30), and 40 mmHg (G40)], that were maintained for 3 and 5 h. APP, pHi, and Lc were measured and ileal biopsies taken laparoscopically every 30 min. The mucosal damage was graded using the standardized Park's Score and animals were classified as injured (I+) or uninjured (I-). Different histopathological lesions were observed in groups G20, G30, and G40 but no damage observed in group C. A 33.3% of animals in G20 and G30 were I+ after 3 h, while 93.3% were injured in G40. After 5 h, histopathological lesions were no longer seen in some animals in G20 and only 10% were I+. Conversely, in G30 I+ pigs increased to 80% while those in G40 remained at 93.3% I+. The I+ animals had significantly lower APP and pHi than those I-. Lc was the clinical parameter that showed the earliest differences, with significantly higher figures in I+ animals. The evolution of intestinal injuries from pneumoperitoneum-induced IAH depends on the degree of IAP. These damages may be associated with decreases in APP and pHi, and increases in Lc.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 20%
Unknown 4 80%

Demographic breakdown

Readers by professional status Count As %
Professor 1 20%
Student > Postgraduate 1 20%
Student > Ph. D. Student 1 20%
Researcher 1 20%
Unspecified 1 20%
Other 0 0%
Readers by discipline Count As %
Unspecified 2 40%
Veterinary Science and Veterinary Medicine 1 20%
Psychology 1 20%
Social Sciences 1 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2018.
All research outputs
#7,136,456
of 11,927,787 outputs
Outputs from Surgical Endoscopy
#1,990
of 3,490 outputs
Outputs of similar age
#138,805
of 256,963 outputs
Outputs of similar age from Surgical Endoscopy
#31
of 55 outputs
Altmetric has tracked 11,927,787 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,490 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 256,963 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.