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Intestinal histopathological changes in a porcine model of pneumoperitoneum-induced intra-abdominal hypertension

Overview of attention for article published in Surgical Endoscopy, May 2018
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Title
Intestinal histopathological changes in a porcine model of pneumoperitoneum-induced intra-abdominal hypertension
Published in
Surgical Endoscopy, May 2018
DOI 10.1007/s00464-018-6142-z
Pubmed ID
Authors

Ester Párraga Ros, Laura Correa-Martín, Francisco M. Sánchez-Margallo, Irma Eugenia Candanosa-Aranda, Manu L. N. G. Malbrain, Robert Wise, Rafael Latorre, Octavio López Albors, Gregorio Castellanos

Abstract

Low splanchnic perfusion is an immediate effect of pneumoperitoneum-induced intra-abdominal hypertension (IAH). Anatomical structure results in the intestinal mucosa being the area most sensitive to hypoperfusion. The relationship between intestinal injury and clinical parameters of tissue perfusion [abdominal perfusion pressure (APP), gastric intramucosal pH (pHi) and lactic acid (Lc)] has not been previously studied. This study aimed to monitorize intestinal pathogenesis through sequential ileal biopsies and to measure APP, pHi, and Lc levels at different pneumoperitoneum-induced intra-abdominal pressures (20, 30, and 40 mmHg) to evaluate the potential relationships between them. Fifty pigs were divided into four groups; a control group (C) and three experimental groups with different pneumoperitoneum-induced levels [20 mmHg (G20), 30 mmHg (G30), and 40 mmHg (G40)], that were maintained for 3 and 5 h. APP, pHi, and Lc were measured and ileal biopsies taken laparoscopically every 30 min. The mucosal damage was graded using the standardized Park's Score and animals were classified as injured (I+) or uninjured (I-). Different histopathological lesions were observed in groups G20, G30, and G40 but no damage observed in group C. A 33.3% of animals in G20 and G30 were I+ after 3 h, while 93.3% were injured in G40. After 5 h, histopathological lesions were no longer seen in some animals in G20 and only 10% were I+. Conversely, in G30 I+ pigs increased to 80% while those in G40 remained at 93.3% I+. The I+ animals had significantly lower APP and pHi than those I-. Lc was the clinical parameter that showed the earliest differences, with significantly higher figures in I+ animals. The evolution of intestinal injuries from pneumoperitoneum-induced IAH depends on the degree of IAP. These damages may be associated with decreases in APP and pHi, and increases in Lc.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 14%
Student > Bachelor 2 14%
Student > Doctoral Student 1 7%
Student > Ph. D. Student 1 7%
Professor 1 7%
Other 0 0%
Unknown 7 50%
Readers by discipline Count As %
Medicine and Dentistry 3 21%
Veterinary Science and Veterinary Medicine 1 7%
Economics, Econometrics and Finance 1 7%
Engineering 1 7%
Unknown 8 57%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2018.
All research outputs
#14,400,429
of 23,063,209 outputs
Outputs from Surgical Endoscopy
#3,285
of 6,117 outputs
Outputs of similar age
#185,698
of 328,278 outputs
Outputs of similar age from Surgical Endoscopy
#51
of 97 outputs
Altmetric has tracked 23,063,209 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,117 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
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We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.