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Ameliorative effect of ginseng extract on phthalate and bisphenol A reprotoxicity during pregnancy in rats

Overview of attention for article published in Environmental Science & Pollution Research, May 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

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4 tweeters

Citations

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5 Dimensions

Readers on

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14 Mendeley
Title
Ameliorative effect of ginseng extract on phthalate and bisphenol A reprotoxicity during pregnancy in rats
Published in
Environmental Science & Pollution Research, May 2018
DOI 10.1007/s11356-018-2299-1
Pubmed ID
Authors

Islam M. Saadeldin, Mohamed A. Hussein, Aida Hamid Suleiman, Mahmoud G. Abohassan, Mona M. Ahmed, Amr A. Moustafa, Abdullah F. Moumen, Ayman Abdel-Aziz Swelum

Abstract

Phthalates (such as DEHP) and bisphenol A (BPA) are widely used chemicals in plastics manufacturing and exert public health concerns as endocrine disrupters. This study was designed to investigate the deleterious effect of DEHP and BPA on endocrine profile of pregnant female rats and the combined treatment with ginseng extract (Panax ginseng). Seventy-two pregnant rats were divided into six groups (control, ginseng, DEHP, BPA, Gin + DEHP, and Gin + BPA), 12 females per each group. The drugs were supplemented from pregnancy day 0 until day 20. Determination of serum sex hormones (testosterone, progesterone, and estradiol) were determined on days 4, 10, and 20 of pregnancy. mRNA transcripts of STAR, HSD17B3, CYP17, AKT1, and PTEN were relatively quantified against ACTB in the ovary and placenta of days 10 and 20 pregnant females by relative quantitative polymerase-chain reaction (RQ-PCR). DEHP and BPA significantly decreased the endocrine profile of testosterone, progesterone, and estradiol of days 10 and 20 of pregnant females. Combined administration of these chemicals along with ginseng extracts has returned the hormones to normal levels when compared with the control group. The ovarian and placental CYP17 and HSD17B3 mRNA transcripts showed variable expression pattern in both tissues and they were significantly affected by DEHP and BPA administration, concomitantly correlating to STAR, AKT1, PTEN, progesterone, and testosterone levels on pregnancy days 10 and 20. The results confirm the reprotoxicity of DEHP and BPA as endocrine disruptors and indicate that ginseng could be used to alleviate the toxic effects of these chemicals.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 6 43%
Student > Bachelor 3 21%
Professor > Associate Professor 3 21%
Other 1 7%
Librarian 1 7%
Other 0 0%
Readers by discipline Count As %
Unspecified 7 50%
Veterinary Science and Veterinary Medicine 3 21%
Biochemistry, Genetics and Molecular Biology 2 14%
Agricultural and Biological Sciences 1 7%
Medicine and Dentistry 1 7%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2019.
All research outputs
#6,782,517
of 13,171,980 outputs
Outputs from Environmental Science & Pollution Research
#806
of 3,657 outputs
Outputs of similar age
#111,164
of 269,398 outputs
Outputs of similar age from Environmental Science & Pollution Research
#26
of 150 outputs
Altmetric has tracked 13,171,980 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,657 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,398 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 150 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.