↓ Skip to main content

Determination of subcutaneous tumor size in athymic (nude) mice

Overview of attention for article published in Cancer Chemotherapy & Pharmacology, September 1989
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#43 of 1,711)
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

patent
18 patents

Citations

dimensions_citation
944 Dimensions

Readers on

mendeley
320 Mendeley
Title
Determination of subcutaneous tumor size in athymic (nude) mice
Published in
Cancer Chemotherapy & Pharmacology, September 1989
DOI 10.1007/bf00300234
Pubmed ID
Authors

Mary M. Tomayko, C. Patrick Reynolds

Abstract

The athymic (nude) mouse is a useful model for studying the biology and response to therapies of human tumors in vivo. A survey of recent literature revealed the use of 19 different formulas for determining the size of subcutaneous tumors grown as xenografts in nude mice (2 for determining tumor area, 3 for tumor diameter, and 14 for calculating tumor volume). We compared the volumes, areas, and diameters predicted by each of the 19 formulas with the actual weights of 50 tumors ranging from 0.46 to 22.0 g established in nude mice as xenografts from human cell lines. In addition to determining how well each formula predicted relative tumor size, we analyzed how well each formula estimated actual tumor mass. The ellipsoid volume formulas (pi/6 x L x W x H and 1/2 x L x W x H) were best for estimating tumor mass (r = 0.93), whereas measurements of diameter correlated poorly with tumor mass (r less than 0.66). Although determination of tumor area correlated well with tumor mass in small tumors (r = 0.89), correlations of area with tumor mass for large tumors were poor (r = 0.41). We conclude that determination of the ellipsoid volume from measurements of three axes consistently yields the most accurate estimations of both relative and actual tumor mass.

Mendeley readers

The data shown below were compiled from readership statistics for 320 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
Portugal 2 <1%
United States 2 <1%
Brazil 1 <1%
Italy 1 <1%
South Africa 1 <1%
Korea, Republic of 1 <1%
Argentina 1 <1%
Canada 1 <1%
Other 0 0%
Unknown 308 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 100 31%
Researcher 68 21%
Student > Master 42 13%
Student > Bachelor 31 10%
Unspecified 30 9%
Other 49 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 92 29%
Medicine and Dentistry 59 18%
Biochemistry, Genetics and Molecular Biology 50 16%
Unspecified 45 14%
Engineering 16 5%
Other 58 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2017.
All research outputs
#1,389,998
of 12,104,225 outputs
Outputs from Cancer Chemotherapy & Pharmacology
#43
of 1,711 outputs
Outputs of similar age
#51,089
of 256,361 outputs
Outputs of similar age from Cancer Chemotherapy & Pharmacology
#2
of 19 outputs
Altmetric has tracked 12,104,225 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,711 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 256,361 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.