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Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin

Overview of attention for article published in Naunyn-Schmiedeberg's Archives of Pharmacology, August 2001
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#13 of 1,758)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
3 news outlets
blogs
1 blog
patent
9 patents
video
1 YouTube creator

Citations

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52 Dimensions

Readers on

mendeley
54 Mendeley
citeulike
1 CiteULike
Title
Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology, August 2001
DOI 10.1007/s002100100427
Pubmed ID
Authors

Celme Vieira, Steffen Fetzer, Susanne K. Sauer, Stefano Evangelista, Beate Averbeck, Michaela Kress, Peter W. Reeh, Rocco Cirillo, Annalisa Lippi, Carlo A. Maggi, Stefano Manzini

Abstract

We have investigated the pro- and anti-inflammatory effects of ricinoleic acid (RA), the main active principle of castor oil, in an experimental model of blepharitis induced by intradermal injection of carrageenan in the guinea-pig eyelid and its possible capsaicin-like mode of action on acutely dissociated rat dorsal root ganglia (DRG) neurons in vitro. Topical treatment with RA (10-100 mg/guinea-pig) or capsaicin (1-10 mg/guinea-pig) caused eyelid reddening and oedema. At lower doses (0.3-3 mg/guinea-pig and 0.009-0.09 mg/guinea-pig for RA and capsaicin, respectively) both drugs significantly potentiated the eyelid oedema induced by carrageenan. The tachykinin NK1 receptor antagonist FK 888 (0.59 mg/kg s.c.) abolished the potentiation of carrageenan-induced eyelid oedema induced by either RA or capsaicin. The neutral endopeptidase inhibitor, thiorphan (1.3 mg/kg i.v.) significantly enhanced the potentiation of carrageenan-induced eyelid oedema produced by RA. This potentiating effect was abolished by FK 888. Repeated (8 days) topical application of RA (0.9 mg/guinea-pig) or capsaicin (0.09 mg/guinea-pig) inhibited the carrageenan-induced eyelid oedema. This anti-inflammatory effect was accompanied by a reduction (75%-80% of SP and 46%-51% of NKA) in tachykinin content of the eyelids, as determined by radioimmunoassay. In dissociated rat DRG neurons, RA (0.1 mM for 5 min) significantly inhibited the inward currents induced by application of capsaicin (1 microM) and/or low pH (5.8), without inducing any currents by itself or changing voltage-dependent currents. Moreover, after 24-h incubation, RA (0.1 mM) significantly decreased the capsaicin (1 microM)-induced calcitonin gene-related peptide (CGRP) release from rat DRG neurons, whereas acute drug superfusion did not evoke CGRP release by itself. Summarizing, RA possesses capsaicin-like dual pro-inflammatory and anti-inflammatory properties which are observed upon acute and repeated application, respectively. However, unlike capsaicin, RA does not induce inward current in DRG neurons and it is devoid of algesic properties in vivo.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Egypt 2 4%
Australia 1 2%
United States 1 2%
Unknown 50 93%

Demographic breakdown

Readers by professional status Count As %
Other 7 13%
Student > Master 7 13%
Researcher 7 13%
Student > Ph. D. Student 6 11%
Student > Doctoral Student 5 9%
Other 11 20%
Unknown 11 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 19%
Chemistry 9 17%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Veterinary Science and Veterinary Medicine 3 6%
Medicine and Dentistry 3 6%
Other 13 24%
Unknown 12 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2022.
All research outputs
#1,058,903
of 23,206,358 outputs
Outputs from Naunyn-Schmiedeberg's Archives of Pharmacology
#13
of 1,758 outputs
Outputs of similar age
#667
of 38,627 outputs
Outputs of similar age from Naunyn-Schmiedeberg's Archives of Pharmacology
#1
of 7 outputs
Altmetric has tracked 23,206,358 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,758 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 38,627 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them