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RETRACTED ARTICLE: Decreased miR-154 expression and its clinical significance in human colorectal cancer

Overview of attention for article published in World Journal of Surgical Oncology, June 2015
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Title
RETRACTED ARTICLE: Decreased miR-154 expression and its clinical significance in human colorectal cancer
Published in
World Journal of Surgical Oncology, June 2015
DOI 10.1186/s12957-015-0607-5
Pubmed ID
Authors

Yang Kai, Cheng Qiang, Pan Xinxin, Zhou Miaomiao, Lin Kuailu

Abstract

miRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers. However, its clinical significance in colorectal cancer (CRC) is still unclear. The aim of this study was to analyze the association of miR-154 expression with clinicopathologic features and prognosis in CRC patients. Quantitative RT-PCR was performed to evaluate miR-154 levels in 169 pairs of CRC specimens and adjacent noncancerous tissues. Then, the associations of miR-154 expression with clinicopathological factors or survival of patients suffering CRC were determined. The expression levels of miR-154 in CRC tissues were significantly lower than those in corresponding noncancerous tissues (P < 0.001). Decreased miR-154 expression was significantly associated with large tumor size, positive lymph node metastasis, and advanced clinical stage. Moreover, the univariate analysis demonstrated that CRC patients with low miR-154 expression had poorer overall survival (P = 0.006). The multivariate analysis identified low miR-154 expression as an independent predictor of poor survival. These findings suggested that miR-154 downregulation may be associated with tumor progression of CRC, and that this miR may be an independent prognostic marker for CRC patients.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 44%
Student > Master 3 19%
Researcher 2 13%
Student > Bachelor 2 13%
Student > Postgraduate 1 6%
Other 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 38%
Biochemistry, Genetics and Molecular Biology 5 31%
Medicine and Dentistry 2 13%
Nursing and Health Professions 2 13%
Unspecified 1 6%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2015.
All research outputs
#4,328,624
of 5,199,662 outputs
Outputs from World Journal of Surgical Oncology
#996
of 1,128 outputs
Outputs of similar age
#143,668
of 175,981 outputs
Outputs of similar age from World Journal of Surgical Oncology
#47
of 48 outputs
Altmetric has tracked 5,199,662 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,128 research outputs from this source. They receive a mean Attention Score of 1.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.