Title |
The brain’s Geppetto—microbes as puppeteers of neural function and behaviour?
|
---|---|
Published in |
Journal of NeuroVirology, June 2015
|
DOI | 10.1007/s13365-015-0355-x |
Pubmed ID | |
Authors |
Roman M. Stilling, Timothy G. Dinan, John F. Cryan |
Abstract |
Research on the microbiome and its interaction with various host organs, including the brain, is increasingly gaining momentum. With more evidence establishing a comprehensive microbiota-gut-brain axis, questions have been raised as to the extent to which microbes influence brain physiology and behaviour. In parallel, there is a growing literature showing active behavioural manipulation in favour of the microbe for certain parasites. However, it seems unclear where the hidden majority of microbes are localised on the parasitism-mutualism spectrum. A long evolutionary history intimately connects host and microbiota, which complicates this classification. In this conceptual minireview, we discuss current hypotheses on host-microbe interaction and argue that novel experimental approaches and theoretical concepts, such as the hologenome theory, are necessary to incorporate transgenerational epigenetic inheritance of the microbiome into evolutionary theories. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 5 | 15% |
Ireland | 3 | 9% |
France | 2 | 6% |
United States | 2 | 6% |
Denmark | 1 | 3% |
Dominican Republic | 1 | 3% |
Hong Kong | 1 | 3% |
Italy | 1 | 3% |
Germany | 1 | 3% |
Other | 0 | 0% |
Unknown | 17 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 24 | 71% |
Scientists | 8 | 24% |
Science communicators (journalists, bloggers, editors) | 2 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Netherlands | 1 | <1% |
Ireland | 1 | <1% |
Italy | 1 | <1% |
United States | 1 | <1% |
Luxembourg | 1 | <1% |
Unknown | 132 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 17% |
Researcher | 20 | 14% |
Student > Bachelor | 15 | 11% |
Student > Master | 14 | 10% |
Other | 13 | 9% |
Other | 34 | 25% |
Unknown | 19 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 37 | 27% |
Medicine and Dentistry | 24 | 17% |
Biochemistry, Genetics and Molecular Biology | 16 | 12% |
Neuroscience | 8 | 6% |
Psychology | 7 | 5% |
Other | 21 | 15% |
Unknown | 25 | 18% |