Title |
An Open-Label Study of Controlled-Release Melatonin in Treatment of Sleep Disorders in Children with Autism
|
---|---|
Published in |
Journal of Autism and Developmental Disorders, August 2006
|
DOI | 10.1007/s10803-006-0116-z |
Pubmed ID | |
Authors |
F. Giannotti, F. Cortesi, A. Cerquiglini, P. Bernabei |
Abstract |
Long-term effectiveness of controlled-release melatonin in 25 children, aged 2.6-9.6 years with autism without other coexistent pathologies was evaluated openly. Sleep patterns were studied using Children's Sleep Habits Questionnaire (CSHQ) and sleep diaries at baseline, after 1-3-6 months melatonin treatment and 1 month after discontinuation. Sleep diary and CSHQ showed a more problematic sleep in autistic children compared with controls. During treatment sleep patterns of all children improved. After discontinuation 16 children returned to pre-treatment score, readministration of melatonin was again effective. Treatment gains were maintained at 12 and 24-month follow-ups. No adverse side effects were reported. In conclusion, controlled-release melatonin may provide an effective and well-tolerated treatment for autistic children with chronic sleep disorders. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Australia | 1 | <1% |
Netherlands | 1 | <1% |
Japan | 1 | <1% |
Spain | 1 | <1% |
Unknown | 157 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 23 | 14% |
Researcher | 19 | 12% |
Student > Ph. D. Student | 19 | 12% |
Student > Bachelor | 16 | 10% |
Other | 12 | 7% |
Other | 36 | 22% |
Unknown | 38 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 43 | 26% |
Psychology | 23 | 14% |
Agricultural and Biological Sciences | 18 | 11% |
Neuroscience | 9 | 6% |
Nursing and Health Professions | 9 | 6% |
Other | 13 | 8% |
Unknown | 48 | 29% |