Title |
Depression increases the onset of cardiovascular disease over and above other determinants in older primary care patients, a cohort study
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Published in |
BMC Cardiovascular Disorders, May 2015
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DOI | 10.1186/s12872-015-0036-y |
Pubmed ID | |
Authors |
Harm W. J. van Marwijk, Koen G. van der Kooy, Coen D. A. Stehouwer, Aartjan T. F. Beekman, Hein P. J. van Hout |
Abstract |
To determine if major depressive disorder (MDD) in older primary care patients is an independent risk factor for cardiovascular events. A cohort of 143 primary care patients with depression and 139 non-depressed controls without depression (both aged over 55 years, matched for age and gender) from the Netherlands was evaluated for 2 years. MDD was diagnosed according to DSM-IV-criteria. During the follow-up period, information was collected on physical health, depression status and behavioural risk factors. CVD end points were assessed with validated annual questionnaires and were crosschecked with medical records. Thirty-four participants experienced a cardiovascular event, of which 71 % were depressed: 27/134 with MDD (20.1 %) and 9/137 controls (6.6 %). MDD was associated with a hazard ratio of 2.83 (p value 0,004, 95 % CI 1.32 to 6.05) for cardiovascular events. After adjustment for cardiovascular medication, the hazard ratio was 2.46 (95 % CI 1.14 to 5.30). In a 2 year follow-up period, baseline MDD increased the risk for CVD in older primary care patients compared with controls, over and above well-known cardiovascular risk factors. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 1 | 20% |
United Kingdom | 1 | 20% |
United States | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Members of the public | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 50 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 19% |
Student > Bachelor | 9 | 17% |
Researcher | 7 | 13% |
Student > Ph. D. Student | 5 | 9% |
Student > Postgraduate | 3 | 6% |
Other | 8 | 15% |
Unknown | 11 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 28% |
Psychology | 8 | 15% |
Nursing and Health Professions | 5 | 9% |
Neuroscience | 3 | 6% |
Social Sciences | 2 | 4% |
Other | 6 | 11% |
Unknown | 14 | 26% |