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Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells

Overview of attention for article published in Nanoscale Research Letters, February 2015
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Title
Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells
Published in
Nanoscale Research Letters, February 2015
DOI 10.1186/s11671-015-0747-0
Pubmed ID
Authors

Sangiliyandi Gurunathan, Jae-Kyo Jeong, Jae Woong Han, Xi-Feng Zhang, Jung Hyun Park, Jin-Hoi Kim

Abstract

Silver nanoparticles (AgNPs) are prominent group of nanomaterials and are recognized for their diverse applications in various health sectors. This study aimed to synthesize the AgNPs using the leaf extract of Artemisia princeps as a bio-reductant. Furthermore, we evaluated the multidimensional effect of the biologically synthesized AgNPs in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma (A549) cells. UV-visible (UV-vis) spectroscopy confirmed the synthesis of AgNPs. X-ray diffraction (XRD) indicated that the AgNPs are specifically indexed to a crystal structure. The results from Fourier transform infrared spectroscopy (FTIR) indicate that biomolecules are involved in the synthesis and stabilization of AgNPs. Dynamic light scattering (DLS) studies showed the average size distribution of the particle between 10 and 40 nm, and transmission electron microscopy (TEM) confirmed that the AgNPs were significantly well separated and spherical with an average size of 20 nm. AgNPs caused dose-dependent decrease in cell viability and biofilm formation and increase in reactive oxygen species (ROS) generation and DNA fragmentation in H. pylori and H. felis. Furthermore, AgNPs induced mitochondrial-mediated apoptosis in A549 cells; conversely, AgNPs had no significant effects on L132 cells. The results from this study suggest that AgNPs could cause cell-specific apoptosis in mammalian cells. Our findings demonstrate that this environmentally friendly method for the synthesis of AgNPs and that the prepared AgNPs have multidimensional effects such as anti-bacterial and anti-biofilm activity against H. pylori and H. felis and also cytotoxic effects against human cancer cells. This report describes comprehensively the effects of AgNPs on bacteria and mammalian cells. We believe that biologically synthesized AgNPs will open a new avenue towards various biotechnological and biomedical applications in the near future.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 1%
United Kingdom 1 <1%
Poland 1 <1%
Unknown 131 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 25%
Student > Master 17 13%
Student > Bachelor 14 10%
Researcher 12 9%
Student > Postgraduate 6 4%
Other 19 14%
Unknown 33 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 18%
Biochemistry, Genetics and Molecular Biology 15 11%
Chemistry 15 11%
Pharmacology, Toxicology and Pharmaceutical Science 10 7%
Engineering 7 5%
Other 23 17%
Unknown 41 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2015.
All research outputs
#16,994,744
of 19,211,930 outputs
Outputs from Nanoscale Research Letters
#665
of 1,035 outputs
Outputs of similar age
#201,562
of 244,007 outputs
Outputs of similar age from Nanoscale Research Letters
#1
of 1 outputs
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So far Altmetric has tracked 1,035 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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