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Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer

Overview of attention for article published in Breast Cancer Research and Treatment, October 2011
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Title
Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer
Published in
Breast Cancer Research and Treatment, October 2011
DOI 10.1007/s10549-011-1799-1
Pubmed ID
Authors

Yunwei Han, Zhihao Yu, Shaoyan Wen, Bin Zhang, Xuchen Cao, Xin Wang

Abstract

Neutropenia is one of the most important dose-limiting toxicities and often the reason for dose reduction. In this study we aimed to assess whether chemotherapy-induced neutropenia could be a marker of efficacy and associate with increased survival. Data from a retrospective survey for early breast cancer patients in our hospital were reviewed. Three hundred and thirty-five patients who had been treated with six cycles of cyclophosphamide, epirubicin, and fluorouracil (CEF) were studied. The association between chemotherapy-induced neutropenia and overall survival (OS) was assessed. According to a multivariate Cox model with time-varying covariates, hazard ratios of death were 0.434 (95% confidence interval (CI), 0.298-0.634; P < 0.001) for patients with mild neutropenia, and 0.640 (95% CI, 0.42-0.975; P = 0.038) for those with severe neutropenia. Neutropenia occurring in early breast cancer patients is an independent predictor of increased survival. These findings suggest that neutropenia in patients who receive chemotherapy is strongly associated with a better prognosis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 18%
Other 5 13%
Researcher 4 10%
Student > Master 4 10%
Professor 2 5%
Other 9 23%
Unknown 9 23%
Readers by discipline Count As %
Medicine and Dentistry 11 28%
Biochemistry, Genetics and Molecular Biology 5 13%
Immunology and Microbiology 4 10%
Agricultural and Biological Sciences 3 8%
Nursing and Health Professions 3 8%
Other 4 10%
Unknown 10 25%