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Structural and dynamic views of GM1 ganglioside

Overview of attention for article published in Glycoconjugate Journal, May 2015
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Title
Structural and dynamic views of GM1 ganglioside
Published in
Glycoconjugate Journal, May 2015
DOI 10.1007/s10719-015-9587-5
Pubmed ID
Authors

Maho Yagi-Utsumi, Koichi Kato

Abstract

The ganglioside GM1 mediates various physiological and pathological processes mainly through the formation of GM1 clusters on cell surfaces. Therefore, detailed characterization of conformational properties of the glycan moiety of GM1 and the structures and interactions of this glycosphingolipid in membrane environments is necessary for better understanding of the clustering-coupled functional promotion. Nuclear magnetic resonance (NMR) spectroscopy has provided conformational information of GM1 in solution as well as in membrane-like environments. Recently, sophisticated paramagnetism-assisted NMR approaches combined with molecular dynamics simulations have enabled the quantitative exploration of conformational spaces of a series of gangliosides, including GM1, taking into account their minor conformations. NMR techniques have also been successfully applied to investigations of the dynamic interactions of GM1 clusters with amyloidogenic proteins such as amyloid β and α-synuclein associated with neurodegenerative disorders. Further integration of experimental and computational approaches will open up new possibilities to provide structural views of the more complicated heterogeneous systems exemplified by microdomains involving GM1.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 41%
Student > Master 4 18%
Student > Bachelor 2 9%
Professor 2 9%
Professor > Associate Professor 1 5%
Other 4 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 27%
Biochemistry, Genetics and Molecular Biology 6 27%
Medicine and Dentistry 2 9%
Chemistry 2 9%
Unspecified 2 9%
Other 4 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2015.
All research outputs
#9,847,365
of 12,329,095 outputs
Outputs from Glycoconjugate Journal
#479
of 580 outputs
Outputs of similar age
#161,408
of 229,693 outputs
Outputs of similar age from Glycoconjugate Journal
#3
of 5 outputs
Altmetric has tracked 12,329,095 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 580 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,693 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.