Title |
In vitro release behavior and cytotoxicity of doxorubicin-loaded gold nanoparticles in cancerous cells
|
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Published in |
Biotechnology Techniques, February 2010
|
DOI | 10.1007/s10529-010-0208-x |
Pubmed ID | |
Authors |
B. Asadishad, M. Vossoughi, I. Alamzadeh |
Abstract |
Doxorubicin (DOX), a common cancer chemotherapeutics, was conjugated to folate-modified thiolated-polyethylene glycol-functionalized gold nanoparticles. The in vitro, controlled release behavior of DOX-loaded gold nanoparticles was observed using porous dialysis membranes (cut-off = 2 kDa). DOX-loaded gold nanoparticles had higher cytotoxicity for folate-receptor-positive cells (KB cells) compared to folate-receptor-negative cells (A549 cells) which were 48 and 62% viable for 10 microM doxorubicin, respectively. This indicates the potential of these nano-carriers for targeted-delivery. In addition, healthy cell viability was 69% for 10 microM free doxorubicin whereas for the same content of drug in DOX-loaded nanoparticles healthy cell viability increased to 80%. |
Mendeley readers
Geographical breakdown
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France | 1 | 2% |
Italy | 1 | 2% |
Brazil | 1 | 2% |
United Kingdom | 1 | 2% |
Spain | 1 | 2% |
Unknown | 38 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 28% |
Student > Master | 7 | 16% |
Researcher | 6 | 14% |
Professor | 3 | 7% |
Student > Postgraduate | 3 | 7% |
Other | 6 | 14% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 14 | 33% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 12% |
Engineering | 4 | 9% |
Materials Science | 4 | 9% |
Medicine and Dentistry | 3 | 7% |
Other | 5 | 12% |
Unknown | 8 | 19% |