Title |
Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) evolution after silicone implants. Who is at risk?
|
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Published in |
Clinical Rheumatology, April 2015
|
DOI | 10.1007/s10067-015-2931-0 |
Pubmed ID | |
Authors |
Idan Goren, Gad Segal, Yehuda Shoenfeld |
Abstract |
Silicone implants have been in use since the mid-twentieth century, especially in the field of reconstructive breast surgery, and have long been considered as biologically inert and harmless. However, growing body of evidence from the past two decades links silicone with subsequent autoimmunity-related complications, collectively known as autoimmune/inflammatory syndrome induced by adjuvant-ASIA. Previous data suggest that while some patients tend to develop post-exposure autoimmune phenomena such as ASIA, other do not. However, thus far, no criteria for risk stratification were suggested. This current review summarizes the data linking silicone implants and autoimmunity, suggesting means of defining individuals who are at increased risk to develop silicone-induced ASIA, and therefore, a recommendation was made to avoid silicone implantation, e.g., individuals with previously diagnosed autoimmune disorders or with genetic preponderance for hyperactive immune system should not be considered as candidates for silicone implantation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 29% |
Venezuela, Bolivarian Republic of | 1 | 14% |
Canada | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 95 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 18 | 19% |
Student > Postgraduate | 14 | 15% |
Student > Bachelor | 10 | 11% |
Researcher | 7 | 7% |
Student > Master | 6 | 6% |
Other | 12 | 13% |
Unknown | 28 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 51 | 54% |
Nursing and Health Professions | 3 | 3% |
Engineering | 3 | 3% |
Arts and Humanities | 2 | 2% |
Psychology | 2 | 2% |
Other | 4 | 4% |
Unknown | 30 | 32% |