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A randomized trial on the efficacy of methylphenidate and modafinil for improving cognitive functioning and symptoms in patients with a primary brain tumor

Overview of attention for article published in Journal of Neuro-Oncology, October 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#46 of 1,644)
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
1 news outlet
twitter
3 tweeters

Citations

dimensions_citation
95 Dimensions

Readers on

mendeley
68 Mendeley
Title
A randomized trial on the efficacy of methylphenidate and modafinil for improving cognitive functioning and symptoms in patients with a primary brain tumor
Published in
Journal of Neuro-Oncology, October 2011
DOI 10.1007/s11060-011-0723-1
Pubmed ID
Authors

K. Gehring, S. Y. Patwardhan, R. Collins, M. D. Groves, C. J. Etzel, C. A. Meyers, J. S. Wefel

Abstract

Limited research is available regarding the efficacy of psychostimulants in treating cognitive function in primary brain tumor patients. An open-label, randomized, pilot trial examined both the general and differential efficacy of 4 weeks of methylphenidate (MPH) and modafinil (MOD) in 24 brain tumor patients. Participants completed cognitive tests and self-report measures of fatigue, sleep disturbance, mood and quality of life at baseline and after 4 weeks.Following stimulant treatment, there was evidence of a beneficial effect on test performance in speed of processing and executive function requiring divided attention. Patients with the greatest deficit in executive function at baseline appeared to derive the greatest benefit following stimulant therapy. Inconsistent, differential effects were found on a measure of attention in favor of MPH and on a measure of processing speed in favor of MOD. There was also evidence of a general beneficial effect on patient-reported measures of fatigue, mood, and quality of life, with no statistically significant differences between treatment arms in these measures over time. The results from this small pilot study should be interpreted with caution, but appear to warrant additional research, in larger study samples, targeting fatigue, processing speed and executive function, and exploring different doses of stimulants. Future studies may also wish to explore the specific patient factors that may be associated with responsiveness to psychostimulant treatment.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 1%
Portugal 1 1%
Italy 1 1%
United States 1 1%
Unknown 64 94%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 9 13%
Student > Bachelor 9 13%
Student > Ph. D. Student 9 13%
Researcher 8 12%
Other 8 12%
Other 25 37%
Readers by discipline Count As %
Medicine and Dentistry 31 46%
Psychology 17 25%
Agricultural and Biological Sciences 6 9%
Unspecified 6 9%
Neuroscience 4 6%
Other 4 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2017.
All research outputs
#1,028,653
of 11,516,709 outputs
Outputs from Journal of Neuro-Oncology
#46
of 1,644 outputs
Outputs of similar age
#8,526
of 96,547 outputs
Outputs of similar age from Journal of Neuro-Oncology
#3
of 41 outputs
Altmetric has tracked 11,516,709 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,644 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,547 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.