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A novel locus on canine chromosome 13 is associated with cataract in the Australian Shepherd breed of domestic dog

Overview of attention for article published in Mammalian Genome, April 2015
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1 tweeter
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3 Facebook pages

Citations

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Readers on

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12 Mendeley
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1 CiteULike
Title
A novel locus on canine chromosome 13 is associated with cataract in the Australian Shepherd breed of domestic dog
Published in
Mammalian Genome, April 2015
DOI 10.1007/s00335-015-9562-2
Pubmed ID
Authors

Sally L. Ricketts, Louise Pettitt, Bryan McLaughlin, Christopher A. Jenkins, Cathryn S. Mellersh

Abstract

Hereditary cataract is a common ocular disorder in the purebred dog population and is a leading cause of visual impairment and blindness in dogs. Despite this, little is known to date about the genetics underlying this condition. We have used a genome-wide association study and targeted resequencing approach to identify a novel locus for cataracts in the Australian Shepherd breed of dog, using dogs that are clear of an HSF4 mutation, previously identified as the major susceptibility locus in this breed. Cataract cases were defined as dogs with bilateral posterior cataracts, or bilateral nuclear cataracts. Controls were at least 8 years of age with no evidence of cataracts or other ocular abnormality. Using 15 bilateral posterior polar cataract cases and 68 controls, we identified a genome-wide statistical association for cataracts in the Australian Shepherd on canine chromosome 13 at 46.4 Mb (P value: 1.5 × 10(-7)). We sequenced the 14.16 Mb associated region in ten Australian Shepherds to search for possible causal variants underlying the association signal and conducted additional fine-mapping of the region by genotyping 28 intronic variants that segregated correctly in our ten sequenced dogs. From this analysis, the strongest associated variants were located in intron 5 of the SCFD2 gene. Further study will require analysis of additional cases and controls and ocular tissue from dogs affected with bilateral cataracts that are free of the HSF4 mutation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 8%
Unknown 11 92%

Demographic breakdown

Readers by professional status Count As %
Other 3 25%
Student > Master 2 17%
Researcher 2 17%
Student > Ph. D. Student 2 17%
Student > Postgraduate 1 8%
Other 2 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 42%
Agricultural and Biological Sciences 4 33%
Veterinary Science and Veterinary Medicine 2 17%
Medicine and Dentistry 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2015.
All research outputs
#7,641,387
of 12,228,633 outputs
Outputs from Mammalian Genome
#863
of 1,008 outputs
Outputs of similar age
#123,161
of 222,685 outputs
Outputs of similar age from Mammalian Genome
#3
of 5 outputs
Altmetric has tracked 12,228,633 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,008 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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