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Genetic polymorphisms among C57BL/6 mouse inbred strains

Overview of attention for article published in Transgenic Research, May 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#34 of 889)
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
3 X users
patent
1 patent

Citations

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161 Dimensions

Readers on

mendeley
242 Mendeley
Title
Genetic polymorphisms among C57BL/6 mouse inbred strains
Published in
Transgenic Research, May 2010
DOI 10.1007/s11248-010-9403-8
Pubmed ID
Authors

Esther Zurita, Mónica Chagoyen, Marta Cantero, Rosario Alonso, Anna González-Neira, Alejandro López-Jiménez, José Antonio López-Moreno, Carlisle P. Landel, Javier Benítez, Florencio Pazos, Lluís Montoliu

Abstract

Mice from the inbred C57BL/6 strain have been commonly used for the generation and analysis of transgenic and knockout animal models. However, several C57BL/6 substrains exist, and these are genetically and phenotypically different. In addition, each of these substrains can be purchased from different animal providers and, in some cases, they have maintained their breeding stocks separated for a long time, allowing genetic differences to accumulate due to individual variability and genetic drift. With the aim of describing the differences in the genotype of several C57BL/6 substrains, we applied the Illumina(®) Mouse Medium Density Linkage Mapping panel, with 1,449 single nucleotide polymorphisms (SNPs), to individuals from ten C57BL/6-related strains: C57BL/6JArc, C57BL/6J from The Jackson Lab, C57BL/6J from Crl, C57BL6/JRccHsd, C57BL/6JOlaHsd, C57BL/6JBomTac, B6(Cg)-Tyr ( c-2j )/J, C57BL/6NCrl, C57BL/6NHsd and C57BL/6NTac. Twelve SNPs were found informative to discriminate among the mouse strains considered. Mice derived from the original C57BL/6J: C57BL/6JArc, C57BL/6J from The Jackson Lab and C57BL/6J from Crl, were indistinguishable. Similarly, all C57BL/6N substrains displayed the same genotype, whereas the additional substrains showed intermediate cases with substrain-specific polymorphisms. These results will be instrumental for the correct genetic monitoring and appropriate mouse colony handling of different transgenic and knockout mice produced in distinct C57BL/6 inbred substrains.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 242 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
Germany 3 1%
Austria 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
France 1 <1%
Spain 1 <1%
Canada 1 <1%
Japan 1 <1%
Other 1 <1%
Unknown 227 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 72 30%
Researcher 62 26%
Student > Master 22 9%
Student > Bachelor 16 7%
Student > Doctoral Student 12 5%
Other 27 11%
Unknown 31 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 95 39%
Biochemistry, Genetics and Molecular Biology 30 12%
Medicine and Dentistry 22 9%
Neuroscience 20 8%
Immunology and Microbiology 14 6%
Other 24 10%
Unknown 37 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2019.
All research outputs
#1,556,108
of 22,653,392 outputs
Outputs from Transgenic Research
#34
of 889 outputs
Outputs of similar age
#5,288
of 95,726 outputs
Outputs of similar age from Transgenic Research
#1
of 11 outputs
Altmetric has tracked 22,653,392 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 889 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,726 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.