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miR-30 overexpression promotes glioma stem cells by regulating Jak/STAT3 signaling pathway

Overview of attention for article published in Tumor Biology, April 2015
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  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

twitter
4 tweeters

Citations

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20 Dimensions

Readers on

mendeley
9 Mendeley
Title
miR-30 overexpression promotes glioma stem cells by regulating Jak/STAT3 signaling pathway
Published in
Tumor Biology, April 2015
DOI 10.1007/s13277-015-3400-8
Pubmed ID
Authors

Shusheng Che, Tingting Sun, Jianpeng Wang, Yingbin Jiao, Chao Wang, Qinghai Meng, Weiguo Qi, Zhiyong Yan

Abstract

Malignant glioma is the most common intracranial tumor with poor prognosis. It is well believed that glioma stem cells (GSCs) are responsible for the initiation and progression of glioma. Janus kinase/signal transducer and activator of transcription (Jak/STAT3) pathway plays a key role in the functions of GSCs. However, the regulatory mechanism of Jak/STAT3 pathway has not been completely elucidated. This study employed multidisciplinary approaches to investigate the upstream regulators of Jak/STAT3 signaling in GSCs. miR-30 was found to be overexpressed in the GSCs derived from U-87 MG and primary glioma cells, compared with non-stem-cell-like glioma cells and normal cells. Downregulation of miR-30 was able to suppress Jak/STAT3 pathway and reduce the tumorigenecity of GSCs. miR-30 decreased the expression of suppressor of cytokine signaling 3 (SOCS3) expression by targeting 3'UTR of its mRNA. The silencing of SOCS3 abolished the effect of miR-30 downregulation on GSCs. Collectively, there is a regulatory pathway consisting of miR-30, SOCS3, and Jak/STAT3 in GSCs, and targeting this pathway may be a promising strategy to treat glioma.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 33%
Student > Ph. D. Student 2 22%
Researcher 2 22%
Student > Doctoral Student 1 11%
Student > Postgraduate 1 11%
Other 0 0%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 44%
Agricultural and Biological Sciences 2 22%
Neuroscience 2 22%
Medicine and Dentistry 1 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2016.
All research outputs
#7,492,624
of 12,428,247 outputs
Outputs from Tumor Biology
#664
of 2,359 outputs
Outputs of similar age
#111,191
of 221,888 outputs
Outputs of similar age from Tumor Biology
#34
of 159 outputs
Altmetric has tracked 12,428,247 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,359 research outputs from this source. They receive a mean Attention Score of 1.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,888 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 159 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.