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Wnt signaling regulation of stem-like properties in human lung adenocarcinoma cell lines

Overview of attention for article published in Medical Oncology, April 2015
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

twitter
3 tweeters

Citations

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12 Dimensions

Readers on

mendeley
7 Mendeley
Title
Wnt signaling regulation of stem-like properties in human lung adenocarcinoma cell lines
Published in
Medical Oncology, April 2015
DOI 10.1007/s12032-015-0596-9
Pubmed ID
Authors

Yan Zhang, Xueyan Zhang, Jinsu Huang, Qianggang Dong

Abstract

The refractory pulmonary adenocarcinoma is characterized by its metastasis and resistance to cytotoxic agents. While the underlying molecular mechanism is unclear, the property of chemoresistance may mainly lie in the presence of highly resistant cancer stem cells. We examined the function of Wnt/β-catenin signaling in maintaining cancer stem cells (CSCs) in lung adenocarcinoma. Lentivirus-mediated knockdown of β-catenin expression accelerated cell cycle. Subsequently, β-catenin knockdown PC9 cells improve the sensitivity to chemotherapy. Further focusing on Wnt signal by administrating PP and EGFR-TKIs as Wnt antagonists can decrease metastasis and induce apoptosis. Collectively, these results indicate that Wnt signaling pathway plays an essential role in maintaining highly resistant CSCs, regulation of cell cycle, metastasis and apoptosis in lung adenocarcinoma.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 29%
Student > Ph. D. Student 2 29%
Student > Master 1 14%
Researcher 1 14%
Student > Doctoral Student 1 14%
Other 0 0%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 57%
Medicine and Dentistry 2 29%
Biochemistry, Genetics and Molecular Biology 1 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2015.
All research outputs
#7,853,794
of 13,029,364 outputs
Outputs from Medical Oncology
#321
of 754 outputs
Outputs of similar age
#110,502
of 223,009 outputs
Outputs of similar age from Medical Oncology
#6
of 40 outputs
Altmetric has tracked 13,029,364 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 754 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,009 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.