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Ligand-Doped Copper Oxo-hydroxide Nanoparticles are Effective Antimicrobials

Overview of attention for article published in Nanoscale Research Letters, April 2018
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Title
Ligand-Doped Copper Oxo-hydroxide Nanoparticles are Effective Antimicrobials
Published in
Nanoscale Research Letters, April 2018
DOI 10.1186/s11671-018-2520-7
Pubmed ID
Authors

Carlos A. P. Bastos, Nuno Faria, Angela Ivask, Olesja M. Bondarenko, Anne Kahru, Jonathan Powell

Abstract

Bacterial resistance to antimicrobial therapies is an increasing clinical problem. This is as true for topical applications as it is for systemic therapy. Topically, copper ions may be effective and cheap antimicrobials that act through multiple pathways thereby limiting opportunities to bacteria for resistance. However, the chemistry of copper does not lend itself to facile formulations that will readily release copper ions at biologically compatible pHs. Here, we have developed nanoparticulate copper hydroxide adipate tartrate (CHAT) as a cheap, safe, and readily synthesised material that should enable antimicrobial copper ion release in an infected wound environment.First, we synthesised CHAT and showed that this had disperse aquated particle sizes of 2-5 nm and a mean zeta potential of - 40 mV. Next, when diluted into bacterial medium, CHAT demonstrated similar efficacy to copper chloride against Escherichia coli and Staphylococcus aureus, with dose-dependent activity occurring mostly around 12.5-50 mg/L of copper. Indeed, at these levels, CHAT very rapidly dissolved and, as confirmed by a bacterial copper biosensor, showed identical intracellular loading to copper ions derived from copper chloride. However, when formulated at 250 mg/L in a topically applied matrix, namely hydroxyethyl cellulose, the benefit of CHAT over copper chloride was apparent. The former yielded rapid sustained release of copper within the bactericidal range, but the copper chloride, which formed insoluble precipitates at such concentration and pH, achieved a maximum release of 10 ± 7 mg/L copper by 24 h.We provide a practical formulation for topical copper-based antimicrobial therapy. Further studies, especially in vivo, are merited.

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Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 20%
Student > Ph. D. Student 2 20%
Student > Master 2 20%
Student > Doctoral Student 1 10%
Unspecified 1 10%
Other 0 0%
Unknown 2 20%
Readers by discipline Count As %
Chemistry 2 20%
Unspecified 1 10%
Environmental Science 1 10%
Energy 1 10%
Agricultural and Biological Sciences 1 10%
Other 2 20%
Unknown 2 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2018.
All research outputs
#10,243,778
of 12,830,933 outputs
Outputs from Nanoscale Research Letters
#384
of 808 outputs
Outputs of similar age
#203,299
of 269,742 outputs
Outputs of similar age from Nanoscale Research Letters
#1
of 1 outputs
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