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Malaria DNA vaccine gp96NTD-CSP elicits both CSP-specific antibody and CD8+ T cell response

Overview of attention for article published in Parasitology Research, March 2015
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Title
Malaria DNA vaccine gp96NTD-CSP elicits both CSP-specific antibody and CD8+ T cell response
Published in
Parasitology Research, March 2015
DOI 10.1007/s00436-015-4429-8
Pubmed ID
Authors

Zhangping Tan, TaoLi Zhou, Hong Zheng, Yan Ding, Wenyue Xu

Abstract

It is ideal for the pre-erythrocytic stage subunit vaccine to induce both CSP-specific antibody and CD8(+) T cell response. Here, we designed a novel malaria DNA vaccine gp96NTD-CSP, which was constructed by fusing the full-length of CSP with the N-terminal domain of gp96 that deleted the endoplasmic reticulum-localized motif KDEL, and investigated its protective efficacy. We found that the fusion protein gp96NTD-CSP was mainly distributed on the surface of eukaryotic cells after transfection and could be sensed as a "danger signal" by the host immune system. Interestingly, both liver parasite burden and parasitemia in mice immunized with gp96NTD-CSP were significantly lower than those in the mice immunized either with gp96NTD, CSP, or gp96NTD-SYVPSAEQI, which was constructed by fusing the CSP-specific CD8(+) T cell epitope with the N-terminal domain of gp96 deleted with KDEL. Consistently, both the level of CSP-specific antibody and the frequency of IFN-γ secreted-CSP-specific CD8(+) T cells were much higher in mice immunized with gp96NTD-CSP than those in the mice immunized either with gp96NTD, CSP, or gp96NTD-SYVPSAEQI. Our results suggest that the malaria DNA vaccine gp96NTD-CSP could induce both humoral and cellular immune responses, which is attributed to the adjuvant effect of gp96NTD and full-length CSP.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 9%
Unknown 10 91%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 27%
Researcher 3 27%
Professor 1 9%
Other 1 9%
Student > Bachelor 1 9%
Other 2 18%
Readers by discipline Count As %
Medicine and Dentistry 5 45%
Immunology and Microbiology 3 27%
Economics, Econometrics and Finance 1 9%
Chemistry 1 9%
Biochemistry, Genetics and Molecular Biology 1 9%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2015.
All research outputs
#10,833,657
of 12,221,286 outputs
Outputs from Parasitology Research
#1,798
of 2,447 outputs
Outputs of similar age
#183,786
of 219,660 outputs
Outputs of similar age from Parasitology Research
#73
of 127 outputs
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