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Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway

Overview of attention for article published in Neuroscience Bulletin, March 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

twitter
2 tweeters

Citations

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20 Dimensions

Readers on

mendeley
32 Mendeley
Title
Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway
Published in
Neuroscience Bulletin, March 2015
DOI 10.1007/s12264-014-1510-8
Pubmed ID
Authors

Barbora Filova, Maria Malinova, Janka Babickova, Lubomira Tothova, Daniela Ostatnikova, Peter Celec, Julius Hodosy

Abstract

Besides their known slow genomic effects, testosterone and estradiol have rapid effects in the brain. However, their impact on mood-related behavior is not clear. The aim of this study was to investigate the non-genomic pathway of testosterone and estradiol in the amygdala in relation to anxiety and depressive-like behavior. Sham-operated and gonadectomized male rats (GDX) supplemented with testosterone propionate, estradiol, or olive oil were used. Five minutes after administration, anxiety and depression-like behavior were tested. Estradiol increased anxiolytic behavior in the open-field test compared to the GDX group, but administration of testosterone had no significant effect. Besides, c-Fos expression in the medial nucleus of the amygdala significantly increased after testosterone treatment compared to the GDX group, while no significant difference was observed in the central and the basolateral nuclei of the amygdala in the testosterone-treated group compared to the GDX group. In conclusion, estradiol had an anxiolytic effect via a rapid pathway, but no rapid effect of testosterone on anxiety was found. Further studies elucidating whether the rapid effect is mediated by a non-genomic pathway are needed.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 19%
Student > Bachelor 6 19%
Student > Master 4 13%
Student > Doctoral Student 3 9%
Other 2 6%
Other 11 34%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 41%
Psychology 7 22%
Neuroscience 6 19%
Unspecified 3 9%
Social Sciences 1 3%
Other 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2015.
All research outputs
#7,230,357
of 12,527,093 outputs
Outputs from Neuroscience Bulletin
#132
of 308 outputs
Outputs of similar age
#98,567
of 217,274 outputs
Outputs of similar age from Neuroscience Bulletin
#7
of 19 outputs
Altmetric has tracked 12,527,093 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 308 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 217,274 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.