| Title |
Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway
|
|---|---|
| Published in |
Neuroscience Bulletin, March 2015
|
| DOI | 10.1007/s12264-014-1510-8 |
| Pubmed ID | |
| Authors |
Barbora Filova, Maria Malinova, Janka Babickova, Lubomira Tothova, Daniela Ostatnikova, Peter Celec, Julius Hodosy |
| Abstract |
Besides their known slow genomic effects, testosterone and estradiol have rapid effects in the brain. However, their impact on mood-related behavior is not clear. The aim of this study was to investigate the non-genomic pathway of testosterone and estradiol in the amygdala in relation to anxiety and depressive-like behavior. Sham-operated and gonadectomized male rats (GDX) supplemented with testosterone propionate, estradiol, or olive oil were used. Five minutes after administration, anxiety and depression-like behavior were tested. Estradiol increased anxiolytic behavior in the open-field test compared to the GDX group, but administration of testosterone had no significant effect. Besides, c-Fos expression in the medial nucleus of the amygdala significantly increased after testosterone treatment compared to the GDX group, while no significant difference was observed in the central and the basolateral nuclei of the amygdala in the testosterone-treated group compared to the GDX group. In conclusion, estradiol had an anxiolytic effect via a rapid pathway, but no rapid effect of testosterone on anxiety was found. Further studies elucidating whether the rapid effect is mediated by a non-genomic pathway are needed. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 24% |
| Student > Bachelor | 7 | 13% |
| Student > Master | 4 | 7% |
| Other | 4 | 7% |
| Student > Doctoral Student | 4 | 7% |
| Other | 11 | 20% |
| Unknown | 12 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 25% |
| Agricultural and Biological Sciences | 12 | 22% |
| Psychology | 7 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Medicine and Dentistry | 2 | 4% |
| Other | 3 | 5% |
| Unknown | 13 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2015.
All research outputs
#14,218,903
of 22,794,367 outputs
Outputs from Neuroscience Bulletin
#316
of 763 outputs
Outputs of similar age
#135,994
of 258,904 outputs
Outputs of similar age from Neuroscience Bulletin
#6
of 15 outputs
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So far Altmetric has tracked 763 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 55% of its peers.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.