| Title |
The innate immune response during urinary tract infection and pyelonephritis
|
|---|---|
| Published in |
Pediatric Nephrology, June 2013
|
| DOI | 10.1007/s00467-013-2513-9 |
| Pubmed ID | |
| Authors |
John David Spencer, Andrew L. Schwaderer, Brian Becknell, Joshua Watson, David S. Hains |
| Abstract |
Despite its proximity to the fecal flora, the urinary tract is considered sterile. The precise mechanisms by which the urinary tract maintains sterility are not well understood. Host immune responses are critically important in the antimicrobial defense of the urinary tract. During recent years, considerable advances have been made in our understanding of the mechanisms underlying immune homeostasis of the kidney and urinary tract. Dysfunctions in these immune mechanisms may result in acute disease, tissue destruction and overwhelming infection. The objective of this review is to provide an overview of the innate immune response in the urinary tract in response to microbial assault. In doing so, we focus on the role of antimicrobial peptides-a ubiquitous component of the innate immune response. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Germany | 1 | <1% |
| Unknown | 181 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 17% |
| Student > Bachelor | 22 | 12% |
| Researcher | 19 | 10% |
| Student > Master | 15 | 8% |
| Student > Doctoral Student | 11 | 6% |
| Other | 36 | 20% |
| Unknown | 50 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 22% |
| Immunology and Microbiology | 23 | 13% |
| Biochemistry, Genetics and Molecular Biology | 23 | 13% |
| Agricultural and Biological Sciences | 21 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Other | 13 | 7% |
| Unknown | 58 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2015.
All research outputs
#20,264,045
of 22,794,367 outputs
Outputs from Pediatric Nephrology
#3,292
of 3,537 outputs
Outputs of similar age
#172,668
of 197,689 outputs
Outputs of similar age from Pediatric Nephrology
#24
of 27 outputs
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We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.