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Engineering Disease Resistant Cattle

Overview of attention for article published in Transgenic Research, October 2005
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#22 of 667)
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
1 news outlet
policy
3 policy sources

Citations

dimensions_citation
47 Dimensions

Readers on

mendeley
67 Mendeley
Title
Engineering Disease Resistant Cattle
Published in
Transgenic Research, October 2005
DOI 10.1007/s11248-005-0670-8
Pubmed ID
Authors

David M. Donovan, David E. Kerr, Robert J. Wall

Abstract

Mastitis is a disease of the mammary gland caused by pathogens that find their way into the lumen of the gland through the teat canal. Mammary gland infections cost the US dairy industry approximately $2 billion dollars annually and have a similar impact in Europe. In the absence of effective treatments or breeding strategies to enhance mastitis resistance, we have created transgenic dairy cows that express lysostaphin in their mammary epithelium and secrete the antimicrobial peptide into milk. Staphylococcus aureus, a major mastitis pathogen, is exquisitely sensitive to lysostaphin. The transgenic cattle resist S. aureus mammary gland challenges, and their milk kills the bacteria, in a dose dependent manner. This first step in protecting cattle against mastitis will be followed by introduction of other genes to deal with potential resistance issues and other mastitis causing organisms. Care will be taken to avoid altering milk's nutritional and manufacturing properties. Multi-cistronic constructs may be required to achieve our goals as will other strategies possibly involving RNAi and gene targeting technology. This work demonstrates the possibility of using transgenic technology to address disease problems in agriculturally important species.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
India 1 1%
Unknown 65 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 24%
Researcher 14 21%
Student > Master 12 18%
Student > Ph. D. Student 5 7%
Other 4 6%
Other 11 16%
Unknown 5 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 39 58%
Biochemistry, Genetics and Molecular Biology 9 13%
Chemistry 3 4%
Veterinary Science and Veterinary Medicine 3 4%
Immunology and Microbiology 2 3%
Other 5 7%
Unknown 6 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2015.
All research outputs
#688,233
of 12,341,272 outputs
Outputs from Transgenic Research
#22
of 667 outputs
Outputs of similar age
#17,739
of 223,794 outputs
Outputs of similar age from Transgenic Research
#2
of 10 outputs
Altmetric has tracked 12,341,272 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 667 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,794 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.