| Title |
EMT and tumor metastasis
|
|---|---|
| Published in |
Clinical and Translational Medicine, February 2015
|
| DOI | 10.1186/s40169-015-0048-3 |
| Pubmed ID | |
| Authors |
Sarah Heerboth, Genevieve Housman, Meghan Leary, Mckenna Longacre, Shannon Byler, Karolina Lapinska, Amber Willbanks, Sibaji Sarkar |
| Abstract |
EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis. We then discuss the signaling pathways and the differential expression and down-regulation of receptors in both tumor cells and stromal cells, which play a role in EMT and metastasis. We further delve into the clinical implications of EMT and MET in several types of tumors, and lastly, we discuss the role of epigenetic events that regulate EMT/MET processes. We hypothesize that reversible epigenetic events regulate both EMT and MET, and thus, also regulate the development of different types of metastatic cancers. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 2 | 29% |
| France | 2 | 29% |
| United States | 1 | 14% |
| Canada | 1 | 14% |
| Germany | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 629 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Portugal | 1 | <1% |
| Italy | 1 | <1% |
| Ukraine | 1 | <1% |
| Romania | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 622 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 129 | 21% |
| Student > Ph. D. Student | 128 | 20% |
| Student > Master | 95 | 15% |
| Researcher | 58 | 9% |
| Student > Doctoral Student | 29 | 5% |
| Other | 71 | 11% |
| Unknown | 119 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 214 | 34% |
| Agricultural and Biological Sciences | 120 | 19% |
| Medicine and Dentistry | 57 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 24 | 4% |
| Engineering | 20 | 3% |
| Other | 60 | 10% |
| Unknown | 134 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2023.
All research outputs
#2,831,804
of 24,228,883 outputs
Outputs from Clinical and Translational Medicine
#106
of 958 outputs
Outputs of similar age
#34,773
of 259,409 outputs
Outputs of similar age from Clinical and Translational Medicine
#2
of 8 outputs
Altmetric has tracked 24,228,883 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 958 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,409 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.