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Rapamycin and mTOR kinase inhibitors

Overview of attention for article published in Journal of Chemical Biology, May 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)

Mentioned by

news
2 news outlets
patent
3 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
216 Dimensions

Readers on

mendeley
474 Mendeley
Title
Rapamycin and mTOR kinase inhibitors
Published in
Journal of Chemical Biology, May 2008
DOI 10.1007/s12154-008-0003-5
Pubmed ID
Authors

Lisa M. Ballou, Richard Z. Lin

Abstract

Mammalian target of rapamycin (mTOR) is a protein kinase that controls cell growth, proliferation, and survival. mTOR signaling is often upregulated in cancer and there is great interest in developing drugs that target this enzyme. Rapamycin and its analogs bind to a domain separate from the catalytic site to block a subset of mTOR functions. These drugs are extremely selective for mTOR and are already in clinical use for treating cancers, but they could potentially activate an mTOR-dependent survival pathway that could lead to treatment failure. By contrast, small molecules that compete with ATP in the catalytic site would inhibit all of the kinase-dependent functions of mTOR without activating the survival pathway. Several non-selective mTOR kinase inhibitors have been described and here we review their chemical and cellular properties. Further development of selective mTOR kinase inhibitors holds the promise of yielding potent anticancer drugs with a novel mechanism of action.

Mendeley readers

The data shown below were compiled from readership statistics for 474 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 2%
United Kingdom 5 1%
Brazil 3 <1%
Poland 1 <1%
France 1 <1%
Germany 1 <1%
Egypt 1 <1%
Philippines 1 <1%
India 1 <1%
Other 0 0%
Unknown 452 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 103 22%
Student > Bachelor 91 19%
Student > Master 78 16%
Researcher 65 14%
Unspecified 33 7%
Other 104 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 178 38%
Biochemistry, Genetics and Molecular Biology 108 23%
Medicine and Dentistry 54 11%
Unspecified 40 8%
Immunology and Microbiology 24 5%
Other 70 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#720,984
of 13,221,142 outputs
Outputs from Journal of Chemical Biology
#1
of 39 outputs
Outputs of similar age
#20,461
of 317,265 outputs
Outputs of similar age from Journal of Chemical Biology
#1
of 3 outputs
Altmetric has tracked 13,221,142 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 39 research outputs from this source. They receive a mean Attention Score of 2.9. This one scored the same or higher as 38 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,265 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them