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Norvaline and Norleucine May Have Been More Abundant Protein Components during Early Stages of Cell Evolution

Overview of attention for article published in Origins of Life & Evolution of the Biosphere, September 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

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1 tweeter
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3 Wikipedia pages

Citations

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13 Dimensions

Readers on

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28 Mendeley
Title
Norvaline and Norleucine May Have Been More Abundant Protein Components during Early Stages of Cell Evolution
Published in
Origins of Life & Evolution of the Biosphere, September 2013
DOI 10.1007/s11084-013-9344-3
Pubmed ID
Authors

Claudia Alvarez-Carreño, Arturo Becerra, Antonio Lazcano

Abstract

The absence of the hydrophobic norvaline and norleucine in the inventory of protein amino acids is readdressed. The well-documented intracellular accumulation of these two amino acids results from the low-substrate specificity of the branched-chain amino acid biosynthetic enzymes that act over a number of related α-ketoacids. The lack of absolute substrate specificity of leucyl-tRNA synthase leads to a mischarged norvalyl-tRNA(Leu) that evades the translational proofreading activities and produces norvaline-containing proteins, (cf. Apostol et al. J Biol Chem 272:28980-28988, 1997). A similar situation explains the presence of minute but detectable amounts of norleucine in place of methionine. Since with few exceptions both leucine and methionine are rarely found in the catalytic sites of most enzymes, their substitution by norvaline and norleucine, respectively, would have not been strongly hindered in small structurally simple catalytic polypeptides during the early stages of biological evolution. The report that down-shifts of free oxygen lead to high levels of intracellular accumulation of pyruvate and the subsequent biosynthesis of norvaline (Soini et al. Microb Cell Factories 7:30, 2008) demonstrates the biochemical and metabolic consequences of the development of a highly oxidizing environment. The results discussed here also suggest that a broader definition of biomarkers in the search for extraterrestrial life may be required.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 3 11%
Canada 2 7%
United Kingdom 1 4%
Slovenia 1 4%
Unknown 21 75%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 25%
Student > Master 6 21%
Researcher 4 14%
Unspecified 3 11%
Other 2 7%
Other 6 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 36%
Biochemistry, Genetics and Molecular Biology 6 21%
Unspecified 3 11%
Computer Science 2 7%
Chemistry 2 7%
Other 5 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2019.
All research outputs
#3,466,352
of 13,350,484 outputs
Outputs from Origins of Life & Evolution of the Biosphere
#83
of 357 outputs
Outputs of similar age
#68,419
of 280,149 outputs
Outputs of similar age from Origins of Life & Evolution of the Biosphere
#1
of 1 outputs
Altmetric has tracked 13,350,484 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 357 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,149 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them