Title |
Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors
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Published in |
Cell Regeneration, July 2014
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DOI | 10.1186/2045-9769-3-10 |
Pubmed ID | |
Authors |
Kamesh Narasimhan, Kevin Micoine, Emmanuel Lacôte, Serge Thorimbert, Edwin Cheung, Bernold Hasenknopf, Ralf Jauch |
Abstract |
SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-polyoxometalate hybrids in targeting different transcription factor families to enable the usage of polyoxometalates as specific SOX transcription factor drugs. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 32% |
Researcher | 4 | 14% |
Student > Bachelor | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Professor > Associate Professor | 2 | 7% |
Other | 3 | 11% |
Unknown | 5 | 18% |
Readers by discipline | Count | As % |
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Chemistry | 10 | 36% |
Biochemistry, Genetics and Molecular Biology | 6 | 21% |
Chemical Engineering | 2 | 7% |
Agricultural and Biological Sciences | 1 | 4% |
Materials Science | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 25% |