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mRNA Stability and the Control of Gene Expression: Implications for Human Disease

Overview of attention for article published in Neurochemical Research, October 2002
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)

Mentioned by

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1 X user
wikipedia
3 Wikipedia pages

Citations

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184 Dimensions

Readers on

mendeley
132 Mendeley
citeulike
1 CiteULike
Title
mRNA Stability and the Control of Gene Expression: Implications for Human Disease
Published in
Neurochemical Research, October 2002
DOI 10.1023/a:1020992418511
Pubmed ID
Authors

Elysia M. Hollams, Keith M. Giles, Andrew M. Thomson, Peter J. Leedman

Abstract

Regulation of gene expression is essential for the homeostasis of an organism, playing a pivotal role in cellular proliferation, differentiation, and response to specific stimuli. Multiple studies over the last two decades have demonstrated that the modulation of mRNA stability plays an important role in regulating gene expression. The stability of a given mRNA transcript is determined by the presence of sequences within an mRNA known as cis-elements, which can be bound by trans-acting RNA-binding proteins to inhibit or enhance mRNA decay. These cis-trans interactions are subject to a control by a wide variety of factors including hypoxia, hormones, and cytokines. In this review, we describe mRNA biosynthesis and degradation, and detail the cis-elements and RNA-binding proteins known to affect mRNA turnover. We present recent examples in which dysregulation of mRNA stability has been associated with human diseases including cancer, inflammatory disease, and Alzheimer's disease.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Netherlands 1 <1%
Sweden 1 <1%
Germany 1 <1%
Unknown 128 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 22%
Researcher 27 20%
Student > Bachelor 17 13%
Student > Master 15 11%
Professor 5 4%
Other 14 11%
Unknown 25 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 37%
Biochemistry, Genetics and Molecular Biology 34 26%
Medicine and Dentistry 8 6%
Neuroscience 4 3%
Computer Science 2 2%
Other 6 5%
Unknown 29 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2023.
All research outputs
#7,960,052
of 25,373,627 outputs
Outputs from Neurochemical Research
#608
of 2,262 outputs
Outputs of similar age
#16,446
of 49,679 outputs
Outputs of similar age from Neurochemical Research
#2
of 4 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,262 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 49,679 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.