Title |
mRNA Stability and the Control of Gene Expression: Implications for Human Disease
|
---|---|
Published in |
Neurochemical Research, October 2002
|
DOI | 10.1023/a:1020992418511 |
Pubmed ID | |
Authors |
Elysia M. Hollams, Keith M. Giles, Andrew M. Thomson, Peter J. Leedman |
Abstract |
Regulation of gene expression is essential for the homeostasis of an organism, playing a pivotal role in cellular proliferation, differentiation, and response to specific stimuli. Multiple studies over the last two decades have demonstrated that the modulation of mRNA stability plays an important role in regulating gene expression. The stability of a given mRNA transcript is determined by the presence of sequences within an mRNA known as cis-elements, which can be bound by trans-acting RNA-binding proteins to inhibit or enhance mRNA decay. These cis-trans interactions are subject to a control by a wide variety of factors including hypoxia, hormones, and cytokines. In this review, we describe mRNA biosynthesis and degradation, and detail the cis-elements and RNA-binding proteins known to affect mRNA turnover. We present recent examples in which dysregulation of mRNA stability has been associated with human diseases including cancer, inflammatory disease, and Alzheimer's disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Netherlands | 1 | <1% |
Sweden | 1 | <1% |
Germany | 1 | <1% |
Unknown | 128 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 22% |
Researcher | 27 | 20% |
Student > Bachelor | 17 | 13% |
Student > Master | 15 | 11% |
Professor | 5 | 4% |
Other | 14 | 11% |
Unknown | 25 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 49 | 37% |
Biochemistry, Genetics and Molecular Biology | 34 | 26% |
Medicine and Dentistry | 8 | 6% |
Neuroscience | 4 | 3% |
Computer Science | 2 | 2% |
Other | 6 | 5% |
Unknown | 29 | 22% |