Epidemiology in wonderland: Big Data and precision medicine

RT @DrMJoyner: @SCSanderson @cecilejanssens @MuinJKhoury @markmccarthyoxf @antonis02 @paulpharoah @skathire See this which has come up in t…

@SCSanderson @cecilejanssens @MuinJKhoury @markmccarthyoxf @antonis02 @paulpharoah @skathire See this which has come up in these sorts of exchanges before.... https://t.co/aV4dwOYH6T also include @stephensenn @f2harrell

RT @DrMJoyner: @cecilejanssens @WiringTheBrain In addition to Cecile’s work see these - screening is hard and getting people to adhere hard…

@cecilejanssens @WiringTheBrain In addition to Cecile’s work see these - screening is hard and getting people to adhere harder.... https://t.co/aV4dwOYH6T https://t.co/aQRAd40quk

@cecilejanssens @MuinJKhoury @RobertCGreen @skathire Pls define “valid” in the context of a screening test & review this https://t.co/aV4dwOYH6T https://t.co/tF6WLwmINo

@cecilejanssens @BrentRichards19 @KenWeiss1 @leonidkruglyak @markmccarthyoxf Agreed...... see this https://t.co/aV4dwOYH6T also beyond their limited utility as a screening tool, good chance that gene scores won’t change behavior in a beneficial way. Gene

RT @DrMJoyner: @cecilejanssens @paulpharoah The false positive false negative elements associated with low AUCs in a condition with modest…

@cecilejanssens @paulpharoah The false positive false negative elements associated with low AUCs in a condition with modest population incidence is the elephant in the room for gene scores. See this https://t.co/aV4dwOH5Ij

@amy_harmon The emerging gene scores for complex traits zeitgeist is full of limitations starting with the stats as @cecilejanssens has pointed out & includes all sorts of cohort specific effects as @NAChristakis has shown for obesity. Many useful cav

@RonZimmernPHG @cecilejanssens @SCSanderson @AndrewElder @CaulfieldTim @MuinJKhoury @MattHancock @VPplenarysesh @MarteauTM Agreed about RR, but see this before you place big bets on RRs in isolation.... show me the Cstats and a prospective trial https://

@SCSanderson @AndrewElder @CaulfieldTim @MuinJKhoury @MattHancock @VPplenarysesh @MarteauTM Should there be some minimal requirements for Cstats and false positives? Or do we blindly accept unfiltered relative risks estimates as magically “actionable”?

RT @DrMJoyner: This might be useful for those interested in gene scores & screening ⁦@antonioregalado⁩ ⁦@matthewherper⁩ ⁦@cecilejanssens⁩ ⁦…

This might be useful for those interested in gene scores & screening ⁦@antonioregalado⁩ ⁦@matthewherper⁩ ⁦@cecilejanssens⁩ ⁦@f2harrell⁩ ⁦@skathire⁩ ⁦@markmccarthyoxf⁩ ⁦@drjohnm⁩ https://t.co/akb3V5HY2y

RT @DeborahLawlor2: Very important read for any epidemiologist or data scientist. Rodolfo Saraci on epidemiology in wonderland- big data &…

Epidemio in wonderland https://t.co/GN4OFEEyp3

RT @GFaghe: A #mustread on the future of #epidemiology and #PrecisionMedicine. Essay published in the European Journal of Epidemiology. htt…

RT @GFaghe: A #mustread on the future of #epidemiology and #PrecisionMedicine. Essay published in the European Journal of Epidemiology. htt…

Excellent - food for the brain - @GFaghe: thanks for spotting https://t.co/1699d0BDdA

A #mustread on the future of #epidemiology and #PrecisionMedicine. Essay published in the European Journal of Epidemiology. https://t.co/z3BVTzwhWq #bigdata #AI https://t.co/I4r3tDpIke

A #mustread on the future of #epidemiology and #PrecisionMedicine. Essay published in the European Journal of Epidemiology. https://t.co/Oec6MPyEWQ #bigdata #AI https://t.co/24iFc4E9pO

#BigData "Epidemiology in wonderland: Big Data and precision medicine." https://t.co/3zo5LJDZ95