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Role of HMG-CoA Reductase Inhibitors in Neurological Disorders

Overview of attention for article published in Drugs, January 2007
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
35 Mendeley
Title
Role of HMG-CoA Reductase Inhibitors in Neurological Disorders
Published in
Drugs, January 2007
DOI 10.2165/00003495-200767150-00001
Pubmed ID
Authors

Allison B Reiss, Elzbieta Wirkowski

Abstract

Inhibitors of HMG-CoA reductase (statins) are cholesterol-lowering agents that dramatically reduce morbidity and mortality in patients with established cardiovascular disease. In addition, they exhibit pleiotropic effects that operate independently of lipid modification. Statin administration results in greater nitric oxide bioavailability, improved endothelial function, enhanced cerebral blood flow, immune modulation with anti-inflammatory action, decreased platelet aggregation and antioxidant activity. Some or all of these effects may improve outcome or ameliorate symptoms in neurological disorders. This article examines the potential role of statins in treating stroke, Alzheimer's disease, multiple sclerosis and Parkinson's disease. Studies are ongoing in this controversial area, but there are no firm conclusions. The appropriateness of initiating statin therapy for neurological disorders is not established at this time. The exception is stroke, in which recurrence is significantly reduced by statin therapy.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Japan 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 29%
Student > Ph. D. Student 7 20%
Student > Master 4 11%
Professor 3 9%
Student > Postgraduate 3 9%
Other 8 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 26%
Medicine and Dentistry 9 26%
Unspecified 6 17%
Psychology 3 9%
Neuroscience 3 9%
Other 5 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2008.
All research outputs
#3,655,193
of 12,566,861 outputs
Outputs from Drugs
#662
of 2,421 outputs
Outputs of similar age
#79,764
of 277,156 outputs
Outputs of similar age from Drugs
#11
of 35 outputs
Altmetric has tracked 12,566,861 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,421 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,156 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.