↓ Skip to main content

Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice

Overview of attention for article published in Genes & Nutrition, February 2009
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
20 Dimensions

Readers on

mendeley
14 Mendeley
Title
Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice
Published in
Genes & Nutrition, February 2009
DOI 10.1007/s12263-009-0110-0
Pubmed ID
Authors

Alessandro Bartolomucci, Elena Bresciani, Ilaria Bulgarelli, Antonello E. Rigamonti, Tiziana Pascucci, Andrea Levi, Roberta Possenti, Antonio Torsello, Vittorio Locatelli, Eugenio E. Muller, Anna Moles

Abstract

The vgf gene regulates energy homeostasis and the VGF-derived peptide TLQP-21 centrally exerts catabolic effects in mice and hamsters. Here, we investigate the effect of chronic intracerebroventricular (icv) injection of TLQP-21 in mice fed high fat diet (HFD). Fast weight-gaining mice injected with the peptide or cerebrospinal fluid were selected for physiological, endocrine, and molecular analysis. TLQP-21 selectively inhibited the increase in body weight and epididymal white adipose tissue (eWAT) weight induced by HFD in control animals despite both groups having a similar degree of hyperphagia. TLQP-21 normalized the increase in leptin and decrease in ghrelin while increasing epinephrine and epinephrine/norepinephrine ratio when compared to values in controls. Finally, HFD-TLQP-21 mice showed a selective increase of eWAT beta3-adrenergic receptor mRNA. Peroxisome-proliferator-activated-receptor-delta and hormone-sensing-lipase mRNA were also upregulated. In conclusion, chronic icv infusion of TLQP-21 prevented the early phase of diet-induced obesity despite overfeeding. These effects were paralleled by activation of catabolic pathways within the eWAT. Our results further support a role for TLQP-21 as a catabolic neuropeptide.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 7%
Brazil 1 7%
Unknown 12 86%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 21%
Professor > Associate Professor 3 21%
Unspecified 2 14%
Student > Doctoral Student 2 14%
Researcher 1 7%
Other 3 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 50%
Unspecified 3 21%
Neuroscience 2 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Medicine and Dentistry 1 7%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2009.
All research outputs
#3,605,747
of 12,445,334 outputs
Outputs from Genes & Nutrition
#101
of 315 outputs
Outputs of similar age
#79,344
of 269,736 outputs
Outputs of similar age from Genes & Nutrition
#3
of 9 outputs
Altmetric has tracked 12,445,334 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 315 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,736 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.