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Expression of a transcriptional factor, SOX6, in human gliomas

Overview of attention for article published in Brain Tumor Pathology, February 2004
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  • Among the highest-scoring outputs from this source (#23 of 169)

Mentioned by

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4 Wikipedia pages

Citations

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32 Dimensions

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11 Mendeley
Title
Expression of a transcriptional factor, SOX6, in human gliomas
Published in
Brain Tumor Pathology, February 2004
DOI 10.1007/bf02482175
Pubmed ID
Authors

Ryo Ueda, Kazunari Yoshida, Yutaka Kawakami, Takeshi Kawase, Masahiro Toda

Abstract

By screening a human testis cDNA library with glioma patients' sera, we isolated a transcriptional factor, SOX6. Here, we analyzed SOX6 expression in gliomas having a range of malignancy grades using immunostaining. Murine Sox6 is a transcriptional factor that is specifically expressed in the developing central nervous system and in the early stages of chondrogenesis in mouse embryos. The reverse transcription-polymerase chain reaction (RT-PCR) revealed that the SOX6 gene was more highly expressed in glioma tissues and fetal brain than in normal adult brain and other cancer cells, except melanoma cells. Immunohistochemical analysis with the anti-SOX6 antibody showed that all the glioma tissues analyzed (14 glioblastomas, 14 anaplastic astrocytomas, 3 anaplastic oligoastrocytomas, 5 diffuse astrocytomas, 1 oligodendroglioma, and 1 pilocytic astrocytoma) expressed SOX6 in tumor cells, but only a few SOX6-positive cells were detected in nonneoplastic tissues from the cerebral cortex. These results indicate that the developmentally regulated transcription factor SOX6 may be a potential diagnostic marker for gliomas.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 9%
Unknown 10 91%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 18%
Researcher 2 18%
Other 1 9%
Professor 1 9%
Student > Doctoral Student 1 9%
Other 2 18%
Unknown 2 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 36%
Biochemistry, Genetics and Molecular Biology 2 18%
Immunology and Microbiology 1 9%
Medicine and Dentistry 1 9%
Engineering 1 9%
Other 0 0%
Unknown 2 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2023.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Brain Tumor Pathology
#23
of 169 outputs
Outputs of similar age
#33,808
of 133,391 outputs
Outputs of similar age from Brain Tumor Pathology
#2
of 2 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 169 research outputs from this source. They receive a mean Attention Score of 1.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 133,391 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.