Uses PRECIS2 checklist (but poorly reported by RCTs): Eligibility Recruitment Setting Organisation Flexibility: delivery Flexibility: adherence Follow-up Primary outcome Primary analysis
Good news: issues were identified, and there is (slow) progress in addressing them https://t.co/KsSZiEz3ge https://t.co/lURSSNjjJo https://t.co/5cnUD52bU8 https://t.co/pF6a8FzFYy https://t.co/PmhFKmlp5K https://t.co/RHJ9nGqOAI https://t.co/ja6633C9pj http
Informative: Dal-Ré, R., Janiaud, P. & Ioannidis, J.P.A. Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic?. BMC Med 16, 49 (2018). https://t.co/EWD63QWaiC @METRICStanford
@RajeevJayadevan •Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/8EZoYNh3MV • Are Novel, Nonrandomized Analytic Methods Fit for Decision Making? The Need for Prospective, Controlled, and Transparent
RT @keithgeraghty: Most medicines RCTs arent really pragmatic, I certainly think their type of default unblinded type CBT trial certainly I…
RT @keithgeraghty: Most medicines RCTs arent really pragmatic, I certainly think their type of default unblinded type CBT trial certainly I…
Most medicines RCTs arent really pragmatic, I certainly think their type of default unblinded type CBT trial certainly Is Not Pragmatic either https://t.co/5HRA4w8eCn https://t.co/0lgwxgHRf1
RT @MattLowPT: Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/tsovSUcyAU
Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/tsovSUcyAU
Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/MuEfEWr2F3
@danrhon Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/dlwHskh1FJ
RT @MedicalEvidence: What is pragmatism? @KirstyLoudon highlights a recent @BMCMedicine article on 'real-world evidence' in her talk at #SC…
RT @CraigSL01: Pragmatism has an interesting philosophical basis. Great to see an exploration of #RCT design from a pragmatic perspective,…
RT @CraigSL01: Pragmatism has an interesting philosophical basis. Great to see an exploration of #RCT design from a pragmatic perspective,…
RT @CraigSL01: Pragmatism has an interesting philosophical basis. Great to see an exploration of #RCT design from a pragmatic perspective,…
RT @MedicalEvidence: What is pragmatism? @KirstyLoudon highlights a recent @BMCMedicine article on 'real-world evidence' in her talk at #SC…
RT @CraigSL01: Pragmatism has an interesting philosophical basis. Great to see an exploration of #RCT design from a pragmatic perspective,…
RT @MedicalEvidence: What is pragmatism? @KirstyLoudon highlights a recent @BMCMedicine article on 'real-world evidence' in her talk at #SC…
RT @MedicalEvidence: What is pragmatism? @KirstyLoudon highlights a recent @BMCMedicine article on 'real-world evidence' in her talk at #SC…
RT @CraigSL01: Pragmatism has an interesting philosophical basis. Great to see an exploration of #RCT design from a pragmatic perspective,…
RT @MedicalEvidence: What is pragmatism? @KirstyLoudon highlights a recent @BMCMedicine article on 'real-world evidence' in her talk at #SC…
RT @MedicalEvidence: What is pragmatism? @KirstyLoudon highlights a recent @BMCMedicine article on 'real-world evidence' in her talk at #SC…
RT @CraigSL01: Pragmatism has an interesting philosophical basis. Great to see an exploration of #RCT design from a pragmatic perspective,…
RT @MedicalEvidence: What is pragmatism? @KirstyLoudon highlights a recent @BMCMedicine article on 'real-world evidence' in her talk at #SC…
RT @MedicalEvidence: What is pragmatism? @KirstyLoudon highlights a recent @BMCMedicine article on 'real-world evidence' in her talk at #SC…
What is pragmatism? @KirstyLoudon highlights a recent @BMCMedicine article on 'real-world evidence' in her talk at #SCT_2018 - read the full article here: https://t.co/q2oRXwMjlw
“Clarity and accuracy on the extent to which a RCT is pragmatic will help understand how much it is relevant to real-world practice.” #ClinicalTrials @BMCMedicine https://t.co/i2VeJwYbBn
RT @BMCMedicine: It's #clinicaltrialsday. Read our latest debate article on How pragmatic are randomized controlled trials labeled as pragm…
It's #clinicaltrialsday. Read our latest debate article on How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/uyoNCvd9hB #ICTD2018
Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? #RCT #EBM https://t.co/XGNxvuzIFQ
RT @Lectoraat_GGZ: PRAGMATISCHE RCT'S | Klinische experimenten (RCT's) kunnen zo worden opgezet dat ze de dagelijkse praktijk zoveel mogeli…
Is the only way to get true results to randomize tests, and how can tests be completely fair if they're randomized? #mchslang19 https://t.co/NwtEsvvVig
Real-world evidence @BMCMedicine How #pragmatic are those #RCTs labelled as pragmatic? An argument for using #PRECIS2 tool https://t.co/gaaf2w1O3t
De kracht van een RCT is nou juist dat ruis zo veel mogelijk ontbreekt. "Real world evidence" is weinig anders dan een eufemisme voor "slecht gecontroleerde studies". https://t.co/makDs5G8nP
RT @Lectoraat_GGZ: PRAGMATISCHE RCT'S | Klinische experimenten (RCT's) kunnen zo worden opgezet dat ze de dagelijkse praktijk zoveel mogeli…
RT @fares_alahdab: "36% of these 89 #trials were #placebo-controlled, performed before licensing of the #medicine, or done in a single-cent…
"36% of these 89 #trials were #placebo-controlled, performed before licensing of the #medicine, or done in a single-center. In our opinion, such #RCTs overtly deviate from usual care and #pragmatism." https://t.co/0iGky10x4j
RT @CHsu1012: Ioannidis: Many self-proclaimed pragmatic trials are in fact not pragmatic. https://t.co/v8y97vK5G4 @UM_IHPI
Ioannidis: Many self-proclaimed pragmatic trials are in fact not pragmatic. https://t.co/v8y97vK5G4 @UM_IHPI
RT @NCI_ImplSci: ICYMI #impsci read in @BMCMedicine by John Ioannidis + colleagues questioning how researchers label their medicine RCTs as…
RT @NCI_ImplSci: ICYMI #impsci read in @BMCMedicine by John Ioannidis + colleagues questioning how researchers label their medicine RCTs as…
ICYMI #impsci read in @BMCMedicine by John Ioannidis + colleagues questioning how researchers label their medicine RCTs as “pragmatic”, & reccs for improvement incl. use of PRECIS-2 #journalclub https://t.co/Kut8BdpHxv https://t.co/Oy2vCag9ZB
RT @Lectoraat_GGZ: PRAGMATISCHE RCT'S | Klinische experimenten (RCT's) kunnen zo worden opgezet dat ze de dagelijkse praktijk zoveel mogeli…
What is a "pragmatic" RCT? https://t.co/YxvtjaiLTS
PRAGMATISCHE RCT'S | Klinische experimenten (RCT's) kunnen zo worden opgezet dat ze de dagelijkse praktijk zoveel mogelijk evenaren. Maar wanneer mag je spreken van een 'pragmatisch' RCT? Wat zijn de criteria? Uitleg en kritische beschouwing: https://t.co/
How pragmatic are the real-world randomized controlled trials? A breakthrough paper by Prof John Ioannidis and his colleagues #RCT #Science @BioMedCentral https://t.co/XruPYgSvWB
Review: Many trials labeled as ‘pragmatic’ are plausibly not very pragmatic; however, impossible for a reader to tell without access to the full protocol and insider knowledge of the trial conduct. https://t.co/awVybcGRgo
1 in 3 randomised controlled trials (#RCT) found to be incorrectly labelled as pragmatic (mimicing usual clinical practice). Insistence on use of the #PRECIS-2 tool by ethics (IRB) committees would have prevented this. https://t.co/iiHq89RtuZ
RT @Trial_Forge: Interesting article from Dal-Ré et al: how pragmatic are trials labelled as pragmatic? Not very in many cases. Authors su…
[OA] Real-World Evidence: How Pragmatic Are Randomized Controlled Trials Labeled As Pragmatic? INTRODUCTION: Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and they are... https://t.co/CTTor4c0Ut
@martinoffringa just as we were discussing trying to track down a comprehensive sample of pediatric pRCTs.... https://t.co/mYP87WZ1j3
RT @Trial_Forge: Interesting article from Dal-Ré et al: how pragmatic are trials labelled as pragmatic? Not very in many cases. Authors su…
RT @Trial_Forge: Interesting article from Dal-Ré et al: how pragmatic are trials labelled as pragmatic? Not very in many cases. Authors su…
Interesting reading. Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/76eAkEHJCG
RT @Trial_Forge: Interesting article from Dal-Ré et al: how pragmatic are trials labelled as pragmatic? Not very in many cases. Authors su…
RT @Trial_Forge: Interesting article from Dal-Ré et al: how pragmatic are trials labelled as pragmatic? Not very in many cases. Authors su…
RT @Trial_Forge: Interesting article from Dal-Ré et al: how pragmatic are trials labelled as pragmatic? Not very in many cases. Authors su…
RT @Trial_Forge: Interesting article from Dal-Ré et al: how pragmatic are trials labelled as pragmatic? Not very in many cases. Authors su…
Interesting article from Dal-Ré et al: how pragmatic are trials labelled as pragmatic? Not very in many cases. Authors suggest greater use of PRECIS-2 tool at the protocol development and grant application stages. https://t.co/WlUoeMKGL9 https://t.co/325t
RT @charlesweijer: Real-world evidence: How #pragmatic are randomized controlled trials #RCTs #labeled as pragmatic? by Rafael Dal-Ré, Perr…
RT @charlesweijer: Real-world evidence: How #pragmatic are randomized controlled trials #RCTs #labeled as pragmatic? by Rafael Dal-Ré, Perr…
RT @charlesweijer: Real-world evidence: How #pragmatic are randomized controlled trials #RCTs #labeled as pragmatic? by Rafael Dal-Ré, Perr…
RT @NaudetFlorian: Interesting paper : Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t…
Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/vtTczBLLvW
RT @josefsenmartin: Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/b9Vq8Mj9Uk
RT @NaudetFlorian: Interesting paper : Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t…
RT @NaudetFlorian: Interesting paper : Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t…
RT @NaudetFlorian: Interesting paper : Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t…
RT @charlesweijer: Real-world evidence: How #pragmatic are randomized controlled trials #RCTs #labeled as pragmatic? by Rafael Dal-Ré, Perr…
Fascinating stuff - should we give more weight to trials labelled 'pragmatic' when making decisions in real-world clinical practice? Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/i11tb42Hfn
RT @charlesweijer: Real-world evidence: How #pragmatic are randomized controlled trials #RCTs #labeled as pragmatic? by Rafael Dal-Ré, Perr…
RT @BMCMedicine: New debate article! Real-world #evidence: How pragmatic are randomized controlled #trials labeled as pragmatic? https://t.…
RT @charlesweijer: Real-world evidence: How #pragmatic are randomized controlled trials #RCTs #labeled as pragmatic? by Rafael Dal-Ré, Perr…
RT @charlesweijer: Real-world evidence: How #pragmatic are randomized controlled trials #RCTs #labeled as pragmatic? by Rafael Dal-Ré, Perr…
Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/b9Vq8Mj9Uk
Pragmatic randomized controlled trial. https://t.co/Q41BMLLAvP
Real-world evidence: How #pragmatic are randomized controlled trials #RCTs #labeled as pragmatic? by Rafael Dal-Ré, Perrine Janiaud and John P. A. #Ioannidis @MedicalEvidence. https://t.co/1DAebfqUI1 https://t.co/4vQm2CNvf2
RT @NaudetFlorian: Interesting paper : Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t…
RT @NaudetFlorian: Interesting paper : Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t…
RT @NaudetFlorian: Interesting paper : Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t…
Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/MqCfEQODAu #trialmethodology
Interesting paper : Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? https://t.co/hknRbLuhSr
New debate article! Real-world #evidence: How pragmatic are randomized controlled #trials labeled as pragmatic? https://t.co/uyoNCvd9hB