Title |
A cDNA clone for a novel nuclear protein with DNA binding activity
|
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Published in |
Chromosoma, October 1992
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DOI | 10.1007/bf00360539 |
Pubmed ID | |
Authors |
Tiziana Mattioni, Clifford R. Hume, Susanna Konigorski, Paula Hayes, Zvi Osterweil, Janet S. Lee |
Abstract |
In an effort to identify trans-acting factors regulating specific genes, we cloned a novel human gene, DBP-5. The cDNA clone contains a predicted open reading frame coding for a potential 1,179 amino acid protein. The mRNA corresponding to DBP-5 is ubiquitously distributed, and the gene is phylogenetically conserved. Immunofluorescence analyses with several cell lines indicate that the protein is localized to the nucleus. Sequence analysis revealed unusual features of the predicted protein structure, including four completely conserved repeats. The phylogenetic conservation of DBP-5, the ubiquity of its expression, its nuclear localization, and its ability to bind DNA sequences, raise the possibility that DBP-5 may play a role in the organization of interphase chromatin and/or in transcriptional regulation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 50% |
Student > Ph. D. Student | 2 | 33% |
Student > Bachelor | 1 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 83% |
Biochemistry, Genetics and Molecular Biology | 1 | 17% |