The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle

RT @donlayman: mTOR has 4 signal inputs leucine via Sestrin2 to Rag; hormones, energy (AMPK) and stress via TSC and Rheb. Aging reduces imp…

RT @donlayman: mTOR has 4 signal inputs leucine via Sestrin2 to Rag; hormones, energy (AMPK) and stress via TSC and Rheb. Aging reduces imp…

RT @donlayman: mTOR has 4 signal inputs leucine via Sestrin2 to Rag; hormones, energy (AMPK) and stress via TSC and Rheb. Aging reduces imp…

RT @donlayman: mTOR has 4 signal inputs leucine via Sestrin2 to Rag; hormones, energy (AMPK) and stress via TSC and Rheb. Aging reduces imp…

RT @donlayman: mTOR has 4 signal inputs leucine via Sestrin2 to Rag; hormones, energy (AMPK) and stress via TSC and Rheb. Aging reduces imp…

RT @mackinprof: @BobKerner3 @donlayman mTOR moves https://t.co/RcdgLwWb60 Closer spatial proximity of complexes to facilitate flux. Mecha…

RT @mackinprof: @BobKerner3 @donlayman mTOR moves https://t.co/RcdgLwWb60 Closer spatial proximity of complexes to facilitate flux. Mecha…

mTOR has 4 signal inputs leucine via Sestrin2 to Rag; hormones, energy (AMPK) and stress via TSC and Rheb. Aging reduces impact of hormones. Resistance Ex increases Sestrin2 sensitivity & inhibits REDD1 (doi: 10.1152/ajpendo.00059.2016). Both mech incr

@BobKerner3 @donlayman mTOR moves https://t.co/RcdgLwWb60 Closer spatial proximity of complexes to facilitate flux. Mechanism for activation mTOR now known https://t.co/kuX1bRWG0a https://t.co/nJ3hJcb7vs The original work https://t.co/6AP2ycgIIe

*rofl* "The putative #leucine sensor Sestrin2 is hyperphosphorylated by acute #resistanceExercise but not #protein ingestion in human skeletal muscle" - someone made a mistake, obviously ;-) In Study 1, 16 males ingested either 10 or... https://t.co/kr6Cz

レジスタンストレーニングとタンパク摂取ではロイシン刺激が異なる　The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle. https://t.co/BCdtOJtkgp

Again, because the in vivo circulating leucine concentrations are never 0, this has not been replicated in vivo. https://t.co/t0pnyC2Gmn

RT @Gommaar: Interesting data showing that sestrin2 is responsive to resistance training and not to increased circulating amino acids (leuc…

RT @Gommaar: Interesting data showing that sestrin2 is responsive to resistance training and not to increased circulating amino acids (leuc…

Interesting data showing that sestrin2 is responsive to resistance training and not to increased circulating amino acids (leucine) in humans. Again showing some strong discrepancy between in vivo and in vitro data. https://t.co/MhjnmknDaQ

Second paper from my PhD! Still looking at Sestrin2! https://t.co/etloGtFDWp

The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle https://t.co/jixvHkpSlw

https://t.co/GUqnMgSBTp good job @nz_zjz

RT @HughesDC_Muscle: The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in…

The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle https://t.co/7FvWwiGevQ