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Precision of regional wall motion estimates from ultra-low-dose cardiac CT using SQUEEZ

Overview of attention for article published in The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging), March 2018
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Title
Precision of regional wall motion estimates from ultra-low-dose cardiac CT using SQUEEZ
Published in
The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging), March 2018
DOI 10.1007/s10554-018-1332-2
Pubmed ID
Authors

Amir Pourmorteza, Noemie Keller, Richard Chen, Albert Lardo, Henry Halperin, Marcus Y. Chen, Elliot McVeigh

Abstract

Resting regional wall motion abnormality (RWMA) has significant prognostic value beyond the findings of computed tomography (CT) coronary angiography. Stretch quantification of endocardial engraved zones (SQUEEZ) has been proposed as a measure of regional cardiac function. The purpose of the work reported here was to determine the effect of lowering the radiation dose on the precision of automatic SQUEEZ assessments of RWMA. Chronic myocardial infarction was created by a 2-h occlusion of the left anterior descending coronary artery in 10 swine (heart rates 80-100, ejection fraction 25-57%). CT was performed 5-11 months post infarct using first-pass contrast enhanced segmented cardiac function scans on a 320-detector row scanner at 80 kVp/500 mA. Images were reconstructed at end diastole and end systole with both filtered back projection and using the "standard" adaptive iterative dose reduction (AIDR) algorithm. For each acquisition, 9 lower dose acquisitions were created. End systolic myocardial function maps were calculated using SQUEEZ for all noise levels and contrast-to-noise ratio (CNR) between the left ventricle blood and myocardium was calculated as a measure of image quality. For acquisitions with CNR > 4, SQUEEZ could be estimated with a precision of ± 0.04 (p < 0.001) or 5.7% of its dynamic range. The difference between SQUEEZ values calculated from AIDR and FBP images was not statistically significant. Regional wall motion abnormality can be quantified with good precision from low dose acquisitions, using SQUEEZ, as long as the blood-myocardium CNR stays above 4.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 33%
Unspecified 1 17%
Student > Master 1 17%
Professor 1 17%
Researcher 1 17%
Other 0 0%
Readers by discipline Count As %
Unspecified 2 33%
Engineering 2 33%
Biochemistry, Genetics and Molecular Biology 1 17%
Medicine and Dentistry 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2018.
All research outputs
#10,068,631
of 11,352,109 outputs
Outputs from The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging)
#625
of 1,069 outputs
Outputs of similar age
#212,808
of 253,928 outputs
Outputs of similar age from The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging)
#14
of 22 outputs
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