Title |
Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats
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Published in |
Cancer Chemotherapy and Pharmacology, November 2010
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DOI | 10.1007/s00280-010-1525-4 |
Pubmed ID | |
Authors |
Izet M. Kapetanovic, Miguel Muzzio, Zhihua Huang, Thomas N. Thompson, David L. McCormick |
Abstract |
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a naturally occurring polyphenol with a broad range of possible health benefits, including anti-cancer activity. However, the biological activity of resveratrol may be limited by poor absorption and first-pass metabolism: only low plasma concentrations of resveratrol are seen following oral administration, and metabolism to glucuronide and sulfate conjugates is rapid. Methylated polyphenol analogs (such as pterostilbene [3,5-dimethoxy-4'-hydroxy-trans-stilbene], the dimethylether analog of resveratrol) may overcome these limitations to pharmacologic efficacy. The present study was designed to compare the bioavailability, pharmacokinetics, and metabolism of resveratrol and pterostilbene following equimolar oral dosing in rats. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | <1% |
Portugal | 1 | <1% |
Sweden | 1 | <1% |
Brazil | 1 | <1% |
Spain | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 255 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 48 | 18% |
Student > Bachelor | 35 | 13% |
Researcher | 33 | 13% |
Student > Master | 29 | 11% |
Student > Doctoral Student | 16 | 6% |
Other | 41 | 16% |
Unknown | 60 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 52 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 36 | 14% |
Biochemistry, Genetics and Molecular Biology | 30 | 11% |
Medicine and Dentistry | 20 | 8% |
Chemistry | 20 | 8% |
Other | 29 | 11% |
Unknown | 75 | 29% |