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Imaging Aβ and tau in early stage Alzheimer’s disease with [18F]AV45 and [18F]AV1451

Overview of attention for article published in EJNMMI Research, March 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)

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45 Mendeley
Title
Imaging Aβ and tau in early stage Alzheimer’s disease with [18F]AV45 and [18F]AV1451
Published in
EJNMMI Research, March 2018
DOI 10.1186/s13550-018-0371-y
Pubmed ID
Authors

Azadeh Firouzian, Alex Whittington, Graham E. Searle, Ivan Koychev, Giovanna Zamboni, Simon Lovestone, Roger N. Gunn

Abstract

AD is a progressive neurodegenerative disorder that is associated with the accumulation of two different insoluble protein aggregates, Aβ plaques and hyperphosphorylated tau. This study aimed to investigate the optimal acquisition and quantification of [18F]AV45 and [18F]AV1451 to image Aβ and tau, respectively, in subjects with AD. Fifteen subjects with early stage AD underwent a T1-weighted structural MRI and two dynamic PET scans to image Aβ (60 min, [18F]AV45) and tau (120 min, [18F]AV1451). Both dynamic BPNDand static SUVR outcome measures were calculated and compared for 12 out of 15 subjects who completed 60 min of the Aβ PET scan and at least 110 min of the tau PET scan. The SRTM and reference Logan graphical analysis were applied to the dynamic data to estimate regional BPNDvalues and SUVR ratios from the static data. Optimal acquisition windows were explored for both the dynamic and static acquisitions. In addition, the spatial correlation between regional Aβ and tau signals was explored. Both the SRTM and graphical analysis methods showed a good fit to the dynamic data for both Aβ and tau dynamic PET scans. Mean regional BPNDestimates became stable 30 min p.i. for [18F]AV45 and 80 min p.i. for [18F]AV1451. Time stability analysis of static SUVR data showed that the outcome measure starts to become stable for scan windows of 30-50 min p.i. for [18F]AV45 and 80-100 min p.i. for [18F]AV1451. The results from these time windows correlated well with the results from the full dynamic analysis for both tracers (R2 = 0.74 for [18F]AV45 and R2 = 0.88 for [18F]AV1451). There was a high correlation between amyloid uptake estimate using both dynamic analysis methods in thalamus and tau uptake in thalamus, hippocampus and amygdala. Short static PET scans at appropriate time windows provided SUVR values which were in reasonable agreement with BPNDvalues calculated from dynamic scans using SRTM and reference Logan. These simplified methods may be appropriate for classification and intervention studies, although caution should be employed when considering interventional studies where blood flow and extraction could change.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 36%
Student > Ph. D. Student 10 22%
Student > Bachelor 3 7%
Lecturer 2 4%
Professor 2 4%
Other 5 11%
Unknown 7 16%
Readers by discipline Count As %
Medicine and Dentistry 10 22%
Computer Science 5 11%
Engineering 5 11%
Psychology 3 7%
Neuroscience 3 7%
Other 5 11%
Unknown 14 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2018.
All research outputs
#10,427,161
of 19,157,982 outputs
Outputs from EJNMMI Research
#133
of 472 outputs
Outputs of similar age
#126,844
of 289,533 outputs
Outputs of similar age from EJNMMI Research
#1
of 1 outputs
Altmetric has tracked 19,157,982 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 472 research outputs from this source. They receive a mean Attention Score of 2.2. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,533 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them