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CD1d and natural T cells: how their properties jump-start the immune system

Overview of attention for article published in Cellular & Molecular Life Sciences, March 2001
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

patent
1 patent
wikipedia
1 Wikipedia page

Citations

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73 Dimensions

Readers on

mendeley
17 Mendeley
Title
CD1d and natural T cells: how their properties jump-start the immune system
Published in
Cellular & Molecular Life Sciences, March 2001
DOI 10.1007/pl00000869
Pubmed ID
Authors

S. Joyce

Abstract

Cellular and humoral immune mechanisms recruited to defend the host from infectious agents depend upon the early immune events triggered by antigen. The cytokine milieu within which the immune response matures is the most important of many factors that govern the nature of the immune response. Natural T cells, whose function is controlled by CD1d molecules, are an early source of cytokines that can bestow type 1 or type 2 differentiative potential upon helper T lymphocytes. This review attempts to illuminate the glycolipid antigen presentation properties of CD1d, how CD1d controls the function of natural T cells and how CD1d and natural T cells interact to jump start the immune system. CD1d is postulated to function as a sensor, sensing alterations in cellular lipid content by virtue of its affinity for such ligands. The presentation of a neo-self glycolipid, presumably by infectious assault of antigen-presenting cells, activates natural T cells, which promptly release pro-inflammatory and anti-inflammatory cytokines and jump-start the immune system.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 6%
Switzerland 1 6%
United Kingdom 1 6%
Unknown 14 82%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 35%
Researcher 3 18%
Student > Bachelor 2 12%
Professor 2 12%
Student > Master 2 12%
Other 2 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 59%
Medicine and Dentistry 2 12%
Immunology and Microbiology 2 12%
Biochemistry, Genetics and Molecular Biology 1 6%
Neuroscience 1 6%
Other 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2013.
All research outputs
#2,096,588
of 12,227,349 outputs
Outputs from Cellular & Molecular Life Sciences
#323
of 2,527 outputs
Outputs of similar age
#53,651
of 270,368 outputs
Outputs of similar age from Cellular & Molecular Life Sciences
#9
of 59 outputs
Altmetric has tracked 12,227,349 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,527 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,368 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.