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Induction of full-length survival motor neuron by polyphenol botanical compounds

Overview of attention for article published in Human Genetics, October 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
wikipedia
1 Wikipedia page

Citations

dimensions_citation
45 Dimensions

Readers on

mendeley
34 Mendeley
Title
Induction of full-length survival motor neuron by polyphenol botanical compounds
Published in
Human Genetics, October 2007
DOI 10.1007/s00439-007-0441-0
Pubmed ID
Authors

Mary S. Sakla, Christian L. Lorson

Abstract

The loss of survival motor neuron-1 (SMN1) is responsible for the development of the neurodegenerative disorder spinal muscular atrophy (SMA). A nearly identical copy of SMN1 is present on the same chromosomal region called SMN2. While SMN2 encodes a normal SMN protein, the majority of SMN2-derived transcripts are alternatively spliced, resulting in a truncated protein that lacks the 16 amino acids encoded by SMN exon 7. Numerous studies have shown that the SMN2-derived protein product, called SMNDelta7, is unstable and dysfunctional. Therefore, identifying molecules that stimulate full-length SMN expression from the SMN2 gene could lead to the development of effective therapies for a broad range of SMA patient populations. Polyphenol compounds have been shown to provide benefit in varied genetic disease contexts. For example, epigallocatechin galate (EGCG) was found to correct aberrant alternative mRNA splicing in familiar dysautonomia (FD). A series of polyphenols were screened and a subset was shown to increase full-length SMN expression from SMN2. Curcumin, EGCG, and resveratrol increased exon 7 inclusion of SMN2 transcripts in transient reporter assays. In SMA patient fibroblasts, these compounds stimulated the production of full-length SMN RNA and protein as well as the formation of SMN-containing nuclear gems. Collectively, these compounds elevated total SMN concentrations in SMA patient fibroblasts, potentially through the modulation of SMN2 exon 7 alternative splicing.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 3%
United Kingdom 1 3%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 26%
Student > Ph. D. Student 8 24%
Student > Master 3 9%
Other 3 9%
Professor 3 9%
Other 8 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 32%
Medicine and Dentistry 8 24%
Biochemistry, Genetics and Molecular Biology 6 18%
Unspecified 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Other 4 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2017.
All research outputs
#1,686,591
of 12,215,443 outputs
Outputs from Human Genetics
#206
of 2,462 outputs
Outputs of similar age
#43,123
of 270,312 outputs
Outputs of similar age from Human Genetics
#2
of 14 outputs
Altmetric has tracked 12,215,443 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,462 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,312 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.