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Linkage analysis and gene expression profile of pancreatic acinar atrophy in the German Shepherd Dog

Overview of attention for article published in Mammalian Genome, December 2005
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

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22 Dimensions

Readers on

mendeley
10 Mendeley
Title
Linkage analysis and gene expression profile of pancreatic acinar atrophy in the German Shepherd Dog
Published in
Mammalian Genome, December 2005
DOI 10.1007/s00335-005-0076-1
Pubmed ID
Authors

Leigh Anne Clark, Jacquelyn M. Wahl, Jörg M. Steiner, Wenli Zhou, Wan Ji, Thomas R. Famula, David A. Williams, Keith E. Murphy

Abstract

Pancreatic acinar atrophy (PAA) is a degenerative disease of the exocrine pancreas and is the most common cause of exocrine pancreatic insufficiency in the German Shepherd Dog. Analyses of inheritance have shown that a single gene segregating in an autosomal recessive fashion is causative for PAA. To date the gene and causative mutation have not been determined. To identify a region of interest and/or candidate genes, we conducted linkage and gene expression studies. Analysis of 384 microsatellite markers resulted in a maximum two-point LOD score of 2.5 for FH2107 on CFA03. We used an oligonucleotide array to generate gene expression profiles for normal and affected pancreata. It revealed 244 genes with greater than two-fold difference in expression levels. Five genes of interest were further assessed by TaqMan quantitative real-time RT-PCR that confirmed trends observed using the microarray. One gene, gp25L, located on CFA03, was found to be downregulated by more than 500-fold in affected pancreata and was further investigated as a candidate gene. Sequence data did not reveal a mutation in the coding sequence that segregates with PAA.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 20%
Finland 1 10%
Unknown 7 70%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 3 30%
Researcher 3 30%
Student > Ph. D. Student 3 30%
Other 1 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 60%
Veterinary Science and Veterinary Medicine 2 20%
Mathematics 1 10%
Medicine and Dentistry 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2007.
All research outputs
#3,501,435
of 12,228,633 outputs
Outputs from Mammalian Genome
#215
of 1,008 outputs
Outputs of similar age
#80,257
of 270,282 outputs
Outputs of similar age from Mammalian Genome
#1
of 5 outputs
Altmetric has tracked 12,228,633 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,008 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,282 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them