| Title |
Linkage analysis and gene expression profile of pancreatic acinar atrophy in the German Shepherd Dog
|
|---|---|
| Published in |
Mammalian Genome, December 2005
|
| DOI | 10.1007/s00335-005-0076-1 |
| Pubmed ID | |
| Authors |
Leigh Anne Clark, Jacquelyn M. Wahl, Jörg M. Steiner, Wenli Zhou, Wan Ji, Thomas R. Famula, David A. Williams, Keith E. Murphy |
| Abstract |
Pancreatic acinar atrophy (PAA) is a degenerative disease of the exocrine pancreas and is the most common cause of exocrine pancreatic insufficiency in the German Shepherd Dog. Analyses of inheritance have shown that a single gene segregating in an autosomal recessive fashion is causative for PAA. To date the gene and causative mutation have not been determined. To identify a region of interest and/or candidate genes, we conducted linkage and gene expression studies. Analysis of 384 microsatellite markers resulted in a maximum two-point LOD score of 2.5 for FH2107 on CFA03. We used an oligonucleotide array to generate gene expression profiles for normal and affected pancreata. It revealed 244 genes with greater than two-fold difference in expression levels. Five genes of interest were further assessed by TaqMan quantitative real-time RT-PCR that confirmed trends observed using the microarray. One gene, gp25L, located on CFA03, was found to be downregulated by more than 500-fold in affected pancreata and was further investigated as a candidate gene. Sequence data did not reveal a mutation in the coding sequence that segregates with PAA. |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 13% |
| Finland | 1 | 7% |
| Unknown | 12 | 80% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 27% |
| Researcher | 4 | 27% |
| Professor > Associate Professor | 3 | 20% |
| Other | 1 | 7% |
| Unknown | 3 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 47% |
| Veterinary Science and Veterinary Medicine | 3 | 20% |
| Mathematics | 1 | 7% |
| Medicine and Dentistry | 1 | 7% |
| Unknown | 3 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2023.
All research outputs
#7,453,350
of 22,786,087 outputs
Outputs from Mammalian Genome
#318
of 1,126 outputs
Outputs of similar age
#38,385
of 148,117 outputs
Outputs of similar age from Mammalian Genome
#2
of 9 outputs
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